| pubmed-article:1517705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0042153 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0242694 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:1517705 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:1517705 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1517705 | pubmed:dateCreated | 1992-10-8 | lld:pubmed |
| pubmed-article:1517705 | pubmed:abstractText | This study investigated the effects of insulin-like growth factor-I (IGF-I) administered to rats in vivo on the soleus muscle isolated from these rats. In order to study the interactions between IGF-I and insulin, the soleus muscles were incubated in the presence of various concentrations of insulin. IGF-I (190-200 micrograms) was given twice daily; the rats were killed 1 h after one injection of IGF-I (acute administration) or after treatment with IGF-I for 10 days (prolonged administration). The level of IGF-I in plasma was increased by approximately 100% after acute administration and by around 30% after 10 days of treatment with IGF-I. Acute administration of IGF-I to the rats increased the flux of glucose to hexose monophosphate and the rates of lactate formation and glycogen synthesis in the soleus muscles; however, the responsiveness of these muscles to insulin was lost: the increase in the rate of glucose utilization by IGF-I at physiological concentrations of insulin (10 or 100 mU/l) was similar to that observed at maximal concentrations of insulin (1000 mU/l). Similar results were obtained after prolonged treatment of the rats with IGF-I; however, the increase in the rate of glucose utilization was less pronounced than when IGF-I was given acutely and the muscles were still capable of responding to insulin.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1517705 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1517705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1517705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1517705 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1517705 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:NewsholmeE... | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:BevanSS | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:KrauseUU | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:TaylorAA | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:DimitriadisGG | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:WegenerGG | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:Parry-Billing... | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:DungerDD | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:ColquhounAA | lld:pubmed |
| pubmed-article:1517705 | pubmed:author | pubmed-author:CalderPP | lld:pubmed |
| pubmed-article:1517705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1517705 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:1517705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1517705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1517705 | pubmed:pagination | 37-43 | lld:pubmed |
| pubmed-article:1517705 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:meshHeading | pubmed-meshheading:1517705-... | lld:pubmed |
| pubmed-article:1517705 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1517705 | pubmed:articleTitle | Effects of in-vivo administration of insulin-like growth factor-I on the rate of glucose utilization in the soleus muscle of the rat. | lld:pubmed |
| pubmed-article:1517705 | pubmed:affiliation | Department of Biochemistry, University of Oxford, U.K. | lld:pubmed |
| pubmed-article:1517705 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1517705 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1517705 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1517705 | lld:pubmed |
