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pubmed-article:1516699pubmed:abstractTextWe have isolated and characterized cDNAs from Hydra which encode antistasin, a potent inhibitor of factor Xa in the vertebrate blood clotting cascade. Hydra antistasin is expressed in gland cells and represents a major class of transcripts from Hydra's head. Sequence analysis revealed that Hydra antistasin contains 6 internal repeats of a 25-26 amino acid sequence with a highly conserved pattern of 6 cysteine and 2 glycine residues identical to that in leech antistasin. Conservation of antistasin in a lower metazoan provides a potential link between the vertebrate and invertebrate coagulation systems.lld:pubmed
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pubmed-article:1516699pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1516699pubmed:articleTitleThe primitive metazoan Hydra expresses antistasin, a serine protease inhibitor of vertebrate blood coagulation: cDNA cloning, cellular localisation and developmental regulation.lld:pubmed
pubmed-article:1516699pubmed:affiliationZoologisches Institut, Universität München, Germany.lld:pubmed
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