| pubmed-article:15166510 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15166510 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15166510 | lifeskim:mentions | umls-concept:C1321489 | lld:lifeskim |
| pubmed-article:15166510 | lifeskim:mentions | umls-concept:C0011900 | lld:lifeskim |
| pubmed-article:15166510 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15166510 | pubmed:dateCreated | 2004-5-28 | lld:pubmed |
| pubmed-article:15166510 | pubmed:abstractText | Muir-Torre syndrome (MTS) is an autosomal dominantly inherited disorder characterized by sebaceous lesions and visceral malignancies. The defect is thought to be the result of a mutation in mismatch repair genes and associated with microsatellite instability. Two cases whose diagnoses were suggested first by the dermatopathologist are discussed. The first is a 47-year-old white man who over the past 6 years developed multiple sebaceous lesions. Due to the number of sebaceous lesions and their morphology, the possible diagnosis of MTS was suggested by the dermatopathologist. Subsequently, a lesion in the right colon was found during colonoscopy that proved to be a poorly differentiated cecal adenocarcinoma. A pedigree analysis revealed other family members afflicted with multiple malignancies. Genetic testing of the colonic adenocarcinoma showed microsatellite instability. The second patient is a 50-year-old white man who underwent biopsy of a skin lesion that showed features of both a sebaceous hyperplasia and sebaceous adenoma. Because of the mixed, unusual features of the lesion, the dermatopathologist suggested the diagnosis of MTS. It was later confirmed that the patient had a history of malignancies of the colon and kidney as well as a family history significant for multiple malignant neoplasms. These cases demonstrate the important role of the dermatopathologist in alerting the clinician to the possibility of Muir-Torre syndrome when the diagnosis of a sebaceous neoplasm is made, especially when unusual histologic features are observed. | lld:pubmed |
| pubmed-article:15166510 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15166510 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166510 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15166510 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166510 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15166510 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15166510 | pubmed:issn | 0193-1091 | lld:pubmed |
| pubmed-article:15166510 | pubmed:author | pubmed-author:MarchYY | lld:pubmed |
| pubmed-article:15166510 | pubmed:author | pubmed-author:CockerellClay... | lld:pubmed |
| pubmed-article:15166510 | pubmed:author | pubmed-author:CurryMary LML | lld:pubmed |
| pubmed-article:15166510 | pubmed:author | pubmed-author:EngWilliamW | lld:pubmed |
| pubmed-article:15166510 | pubmed:author | pubmed-author:PaekDonaldD | lld:pubmed |
| pubmed-article:15166510 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15166510 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:15166510 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15166510 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15166510 | pubmed:pagination | 217-21 | lld:pubmed |
| pubmed-article:15166510 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
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| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:meshHeading | pubmed-meshheading:15166510... | lld:pubmed |
| pubmed-article:15166510 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15166510 | pubmed:articleTitle | Muir-Torre syndrome: role of the dermatopathologist in diagnosis. | lld:pubmed |
| pubmed-article:15166510 | pubmed:affiliation | Division of Dermatopathology, Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. | lld:pubmed |
| pubmed-article:15166510 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15166510 | pubmed:publicationType | Case Reports | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15166510 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15166510 | lld:pubmed |
