| pubmed-article:15166416 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15166416 | lifeskim:mentions | umls-concept:C0376526 | lld:lifeskim |
| pubmed-article:15166416 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15166416 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:15166416 | lifeskim:mentions | umls-concept:C0079183 | lld:lifeskim |
| pubmed-article:15166416 | pubmed:issue | Pt 6 | lld:pubmed |
| pubmed-article:15166416 | pubmed:dateCreated | 2004-5-28 | lld:pubmed |
| pubmed-article:15166416 | pubmed:abstractText | A timely coordination of cellular DNA synthesis and division cycles is governed by the temporal and spatial activation of cyclin-dependent kinases (Cdks). The primary regulation of Cdk activation is through binding to partner cyclin proteins. Several gammaherpesviruses encode a viral homologue of cellular cyclin D, which may function to deregulate host cell cycle progression. One of these is encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) and is called K cyclin or viral cyclin (v-cyclin). v-Cyclin is expressed in most of the malignant cells that are associated with KSHV infection in humans, labelling v-cyclin as a putative viral oncogene. Here are described some of the major structural and functional properties of mammalian cyclin/Cdk complexes, some of which are phenocopied by v-cyclin. In addition, the molecular events leading to orderly progression through the G(1)/S and G/M cell cycle phases are reviewed. This molecular picture serves as a platform on which to explain v-cyclin-specific functional properties. Interesting but largely speculative issues concern the interplay between v-cyclin-mediated cell cycle deregulation and molecular progression of KSHV-associated neoplasms. | lld:pubmed |
| pubmed-article:15166416 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15166416 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15166416 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15166416 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15166416 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:15166416 | pubmed:author | pubmed-author:JonesNicN | lld:pubmed |
| pubmed-article:15166416 | pubmed:author | pubmed-author:EvanGerard... | lld:pubmed |
| pubmed-article:15166416 | pubmed:author | pubmed-author:VerschurenEmm... | lld:pubmed |
| pubmed-article:15166416 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15166416 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:15166416 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15166416 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15166416 | pubmed:pagination | 1347-61 | lld:pubmed |
| pubmed-article:15166416 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15166416 | pubmed:meshHeading | pubmed-meshheading:15166416... | lld:pubmed |
| pubmed-article:15166416 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15166416 | pubmed:articleTitle | The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. | lld:pubmed |
| pubmed-article:15166416 | pubmed:affiliation | Stanford University, Pathology Department, 300 Pasteur Drive, MC 5324, Stanford, CA 94305, USA. | lld:pubmed |
| pubmed-article:15166416 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15166416 | pubmed:publicationType | Review | lld:pubmed |
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