| pubmed-article:15162387 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0008281 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0033798 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:15162387 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:15162387 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15162387 | pubmed:dateCreated | 2004-5-26 | lld:pubmed |
| pubmed-article:15162387 | pubmed:abstractText | A sensitive and specific procedure for simultaneous quantitation of chlorpheniramine and pseudoephedrine in human plasma has been developed and validated. Analytes were extracted from plasma samples by liquid-liquid extraction, separated on a Diamonsil C18 column (250 x 4.6 mm i.d.) and detected by tandem mass spectrometry with an atmospheric pressure chemical ionization interface. Diphenhydramine was used as the internal standard. The method has a lower limit of quantitation of 0.2 and 2.0 ng/mL for chlorpheniramine and pseudoephedrine, respectively. The intra- and inter-day relative standard deviation, calculated from quality control (QC) samples were below 4.3% for chlorpheniramine and below 9.5% for pseudoephedrine. The inter-day relative error as determined from QC samples was within 4.7% for each analyte. The overall extraction recoveries of chlorpheniramine and pseudoephedrine were 77 and 61% on average, respectively. The method was successfully applied to pharmaockinetic study of chlorpheniramine and pseudoephedrine in volunteers receiving formulations containing 4 mg of chlorpheniramine maleate and 60 mg of pseudoephedrine hydrochloride. | lld:pubmed |
| pubmed-article:15162387 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15162387 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15162387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15162387 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15162387 | pubmed:month | May | lld:pubmed |
| pubmed-article:15162387 | pubmed:issn | 0269-3879 | lld:pubmed |
| pubmed-article:15162387 | pubmed:author | pubmed-author:ZhangYongY | lld:pubmed |
| pubmed-article:15162387 | pubmed:author | pubmed-author:ChenXiaoyanX | lld:pubmed |
| pubmed-article:15162387 | pubmed:author | pubmed-author:ZhongDafangD | lld:pubmed |
| pubmed-article:15162387 | pubmed:copyrightInfo | Copyright 2004 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:15162387 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15162387 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15162387 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15162387 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15162387 | pubmed:pagination | 248-53 | lld:pubmed |
| pubmed-article:15162387 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:meshHeading | pubmed-meshheading:15162387... | lld:pubmed |
| pubmed-article:15162387 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15162387 | pubmed:articleTitle | Simultaneous determination of chlorpheniramine and pseudoephedrine in human plasma by liquid chromatography-tandem mass spectrometry. | lld:pubmed |
| pubmed-article:15162387 | pubmed:affiliation | Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, People's Republic of China. | lld:pubmed |
| pubmed-article:15162387 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15162387 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
