| pubmed-article:15157156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15157156 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15157156 | lifeskim:mentions | umls-concept:C0021701 | lld:lifeskim |
| pubmed-article:15157156 | lifeskim:mentions | umls-concept:C1510470 | lld:lifeskim |
| pubmed-article:15157156 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15157156 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15157156 | pubmed:issue | Pt3 | lld:pubmed |
| pubmed-article:15157156 | pubmed:dateCreated | 2004-5-25 | lld:pubmed |
| pubmed-article:15157156 | pubmed:abstractText | Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. Integrins and PAKs also play a role in the control of cell migration. Thus we have discovered a novel protein that links the alpha5beta1 integrin to migration controlled by Rho-family GTPases. This protein, termed Nischarin, is a large cytosolic macromolecule that is not related to well-known protein families. The N-terminus of Nischarin interacts with a short segment of the cytoplasmic domain of the alpha5 integrin subunit. Overexpression of Nischarin alters actin organization and inhibits Rac-driven cell migration and tumour cell invasion. Use of effector domain mutants of Rac suggest that Nischarin acts downstream of Rac, probably at the level of PAK-family kinases. These studies emphasize the intricate connection between integrins and Rho-family GTPases and their effectors in controlling both mitogenesis and migration. | lld:pubmed |
| pubmed-article:15157156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15157156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15157156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15157156 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15157156 | pubmed:issn | 0300-5127 | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:EdinMM | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:JulianoR LRL | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:HoweAA | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:AplinAA | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:AlahariSS | lld:pubmed |
| pubmed-article:15157156 | pubmed:author | pubmed-author:ReddigPP | lld:pubmed |
| pubmed-article:15157156 | pubmed:copyrightInfo | Copyright 2004 Biochemical Society | lld:pubmed |
| pubmed-article:15157156 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15157156 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:15157156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15157156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15157156 | pubmed:pagination | 443-6 | lld:pubmed |
| pubmed-article:15157156 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:meshHeading | pubmed-meshheading:15157156... | lld:pubmed |
| pubmed-article:15157156 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15157156 | pubmed:articleTitle | Integrin regulation of cell signalling and motility. | lld:pubmed |
| pubmed-article:15157156 | pubmed:affiliation | Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. arjay@med.unc.edu | lld:pubmed |
| pubmed-article:15157156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15157156 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15157156 | lld:pubmed |
