| pubmed-article:15153786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15153786 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:15153786 | lifeskim:mentions | umls-concept:C1516213 | lld:lifeskim |
| pubmed-article:15153786 | lifeskim:mentions | umls-concept:C0153690 | lld:lifeskim |
| pubmed-article:15153786 | lifeskim:mentions | umls-concept:C0297331 | lld:lifeskim |
| pubmed-article:15153786 | lifeskim:mentions | umls-concept:C0162491 | lld:lifeskim |
| pubmed-article:15153786 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15153786 | pubmed:dateCreated | 2004-5-21 | lld:pubmed |
| pubmed-article:15153786 | pubmed:abstractText | Diagnosis and follow-up of bone metastases in breast cancer patients usually rely on symptoms and imaging studies. Tartrate-resistant acid phosphatase 5b (TRACP 5b) is a specific marker of osteoclasts and is herein proposed as a marker of bone metastasis in breast cancer patients. An immunoassay using a monoclonal antibody, 14G6, was used to measure the activity of serum TRACP 5b at pH 6.1 in 30 early breast cancer patients without bone metastasis and in 30 aged-matched breast cancer patients with bone metastasis. Another 60 normal volunteers were recruited as controls. Bone alkaline phosphatase (BAP), a traditional marker of bone turnover, was also measured in selected cases. The overall mean TRACP 5b activity in normal women was 2.83 +/- 1.1 U/l, and it increased with age. The mean TRACP 5b activity in early breast cancer patients did not differ from that of the normal group (2.93 +/- 0.64 vs. 2.83 +/- 1.1 U/l; p = 0.66), whereas it was significantly higher in breast cancer patients with bone metastasis (5.42 +/- 2.5 vs. 2.83 +/- 1.1 U/l; p < 0.0001). BAP activity was significantly higher in breast cancer patients with bone metastasis than in early breast cancer patients (p = 0.004). Serum TRACP 5b activity correlated well with BAP activity in breast cancer patients with bone metastasis (p < 0.0001), but not in normal individuals or in patients without bone metastasis. TRACP 5b activity can be considered a surrogate indicator of bone metastasis in breast cancer patients. | lld:pubmed |
| pubmed-article:15153786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15153786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15153786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15153786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15153786 | pubmed:issn | 1021-7770 | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:YamLung TLT | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:HoChing-Liang... | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:ChaoTsu-YiTY | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:LeeSu-HueiSH | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:ChenMary... | lld:pubmed |
| pubmed-article:15153786 | pubmed:author | pubmed-author:JanckilaAntho... | lld:pubmed |
| pubmed-article:15153786 | pubmed:copyrightInfo | Copyright 2004 National Science Council, ROC and S. Karger AG, Basel | lld:pubmed |
| pubmed-article:15153786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15153786 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:15153786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15153786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15153786 | pubmed:pagination | 511-6 | lld:pubmed |
| pubmed-article:15153786 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15153786 | pubmed:meshHeading | pubmed-meshheading:15153786... | lld:pubmed |
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| pubmed-article:15153786 | pubmed:meshHeading | pubmed-meshheading:15153786... | lld:pubmed |
| pubmed-article:15153786 | pubmed:articleTitle | Tartrate-resistant acid phosphatase 5b as a serum marker of bone metastasis in breast cancer patients. | lld:pubmed |
| pubmed-article:15153786 | pubmed:affiliation | Division of Hematology/Oncology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. j0607@ms6.hinet.net | lld:pubmed |
| pubmed-article:15153786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15153786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15153786 | lld:pubmed |
