| pubmed-article:15145981 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0020291 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0008731 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C1325761 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0041004 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0078394 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:15145981 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:15145981 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15145981 | pubmed:dateCreated | 2004-7-15 | lld:pubmed |
| pubmed-article:15145981 | pubmed:abstractText | The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL). However, vldlr-/- mice do not show altered plasma lipoprotein levels, despite reduced LPL expression. Because LPL activity is crucial in postprandial lipid metabolism, we investigated whether the VLDLr plays a role in chylomicron clearance. Fed plasma TG levels of vldlr-/- mice were 2.5-fold increased compared with those of vldlr+/+ littermates (1.20 +/- 0.37 mM vs. 0.47 +/- 0.18 mM; P < 0.001). Strikingly, an intragastric fat load led to a 9-fold increased postprandial TG response in vldlr-/- compared with vldlr+/+ mice (226 +/- 188 mM/h vs. 25 +/- 11 mM/h; P < 0.05). Accordingly, the plasma clearance of [3H]TG-labeled protein-free chylomicron-mimicking emulsion particles was delayed in vldlr-/- compared with vldlr+/+ mice (half-life of 12.0 +/- 2.6 min vs. 5.5 +/- 0.9 min; P < 0.05), with a 60% decreased uptake of label into adipose tissue (P < 0.05). VLDLr deficiency did not affect the plasma half-life and adipose tissue uptake of albumin-complexed [14C]FFA, indicating that the VLDLr facilitates postprandial LPL-mediated TG hydrolysis rather than mediating FFA uptake. We conclude that the VLDLr plays a major role in the metabolism of postprandial lipoproteins by enhancing LPL-mediated TG hydrolysis. | lld:pubmed |
| pubmed-article:15145981 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15145981 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15145981 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15145981 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15145981 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:RomijnJohanne... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:HavekesLouis... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:van DijkKo... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:VosholPeter... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:GoudriaanJelt... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:TeusinkBasB | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:RensenPatrick... | lld:pubmed |
| pubmed-article:15145981 | pubmed:author | pubmed-author:Espirito... | lld:pubmed |
| pubmed-article:15145981 | pubmed:copyrightInfo | Copyright 2004 American Society for Biochemistry and Molecular Biology, Inc. | lld:pubmed |
| pubmed-article:15145981 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15145981 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:15145981 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15145981 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15145981 | pubmed:pagination | 1475-81 | lld:pubmed |
| pubmed-article:15145981 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:meshHeading | pubmed-meshheading:15145981... | lld:pubmed |
| pubmed-article:15145981 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15145981 | pubmed:articleTitle | The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis. | lld:pubmed |
| pubmed-article:15145981 | pubmed:affiliation | Institute for Applied Scientific Research Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands. | lld:pubmed |
| pubmed-article:15145981 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15145981 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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