| pubmed-article:15143159 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15143159 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15143159 | lifeskim:mentions | umls-concept:C0225870 | lld:lifeskim |
| pubmed-article:15143159 | lifeskim:mentions | umls-concept:C1516821 | lld:lifeskim |
| pubmed-article:15143159 | lifeskim:mentions | umls-concept:C1415466 | lld:lifeskim |
| pubmed-article:15143159 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:15143159 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15143159 | pubmed:dateCreated | 2004-5-14 | lld:pubmed |
| pubmed-article:15143159 | pubmed:abstractText | Molecular mechanisms for the dorso-ventral patterning and interventricular septum formation in the embryonic heart are unknown. To investigate a role of Hand1/eHAND in cardiac chamber formation, we generated Hand1/eHAND knock-in mice where Hand1/eHAND cDNA was placed under the control of the MLC2V promoter. In Hand1/eHAND knock-in mice, the outer curvature of the right and left ventricles expanded more markedly. Moreover, there was no interventricular groove or septum formation, although molecularly, Hand1/eHAND knock-in hearts had two ventricles. However, the morphology of the inner curvature of the ventricles, the atrioventricular canal, and the outflow tract was not affected by Hand1/eHAND expression. Furthermore, expression of Hand1/eHAND in the whole ventricles altered the expression patterns of Chisel, ANF, and Hand2/dHAND but did not affect Tbx5 expression. In contrast, the interventricular septum formed normally in transgenic embryos overexpressing Hand1/eHAND in the right ventricle but not in the boundary region. These results suggested that Hand1/eHAND is involved in expansion of the ventricular walls and that absence of Hand1/eHAND expression in the boundary region between the right and left ventricles may be critical in the proper formation of the interventricular groove and septum. Furthermore, Hand1/eHAND is not a master regulatory gene that specifies the left ventricle myocyte lineage but may control the dorso-ventral patterning in concert with additional genes. | lld:pubmed |
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| pubmed-article:15143159 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15143159 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15143159 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15143159 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15143159 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15143159 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:KitaToruT | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:TanakaMakotoM | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:YoshidaYoshin... | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:YamauchiRyoko... | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:KawamotoTakah... | lld:pubmed |
| pubmed-article:15143159 | pubmed:author | pubmed-author:TogiKiyonoriK | lld:pubmed |
| pubmed-article:15143159 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15143159 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15143159 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15143159 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15143159 | pubmed:pagination | 4627-35 | lld:pubmed |
| pubmed-article:15143159 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15143159 | pubmed:meshHeading | pubmed-meshheading:15143159... | lld:pubmed |
| pubmed-article:15143159 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15143159 | pubmed:articleTitle | Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart. | lld:pubmed |
| pubmed-article:15143159 | pubmed:affiliation | Department of Social Service, Kyoto University Hospital, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. makoto@kuhp.kyoto-u.ac.jp | lld:pubmed |
| pubmed-article:15143159 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15143159 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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