Linked Life Data

15134190

Source:http://linkedlifedata.com/resource/pubmed/id/15134190

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pubmed-article:15134190pubmed:abstractTextHepatitis C virus genotype 1B responds poorly to treatment with interferon, in contrast to the more interferon-sensitive genotypes 2 and 3. Studies on combination therapy regimens with PEG-interferon and ribavirin report sustained response rates that generally do not exceed 50%, in contrast to sustained response rates of 80% for genotype 2 and 3. In Japan, a correlation was found between the number of mutations in an 'interferon sensitivity determining region' (ISDR) and outcome of interferon treatment in genotype 1B-infected patients. However, an ongoing controversy on the existence of an ISDR in non-Japanese isolates resulted, as non-Japanese studies failed to confirm this association. The present study approached this issue by carrying out a meta-analysis of ISDR sequences and response to interferon treatment.lld:pubmed
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pubmed-article:15134190pubmed:articleTitleMeta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions.lld:pubmed
pubmed-article:15134190pubmed:affiliationDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands. c.j.schinkel@lumc.nllld:pubmed
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