| pubmed-article:15133948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C0085104 | lld:lifeskim |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C0032521 | lld:lifeskim |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:15133948 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:15133948 | pubmed:dateCreated | 2004-5-11 | lld:pubmed |
| pubmed-article:15133948 | pubmed:abstractText | This work describes the design and synthesis of a novel polymer conjugate to facilitate intracellular release of attached cargo. Water soluble poly[N(2-hydroxypropyl) methacrylamide] with derivatizable pendant side chains was used as the polymer carrier. The membrane active Tat peptide was masked with poly(ethylene glycol) to inhibit non-specific interactions with exterior cell membranes, and then covalently linked to poly[N-(2-hydroxypropyl) methacrylamide]. A novel heterobifunctional crosslinker was synthesized containing both maleimide and aldehyde functionality to allow attachment of peptides to the polymer backbone through a pH sensitive bond. Analysis of the proposed conjugate by gel permeation chromatography, nuclear absorbance spectroscopy, and absorbance measurements indicate that the desired compound has been synthesized. | lld:pubmed |
| pubmed-article:15133948 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15133948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15133948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15133948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15133948 | pubmed:issn | 0067-8856 | lld:pubmed |
| pubmed-article:15133948 | pubmed:author | pubmed-author:ChristieR JRJ | lld:pubmed |
| pubmed-article:15133948 | pubmed:author | pubmed-author:GraingerD WDW | lld:pubmed |
| pubmed-article:15133948 | pubmed:author | pubmed-author:FindleyD JDJ | lld:pubmed |
| pubmed-article:15133948 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15133948 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:15133948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15133948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15133948 | pubmed:pagination | 136-41 | lld:pubmed |
| pubmed-article:15133948 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:meshHeading | pubmed-meshheading:15133948... | lld:pubmed |
| pubmed-article:15133948 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15133948 | pubmed:articleTitle | Design and synthesis of a new polymer drug delivery conjugate. | lld:pubmed |
| pubmed-article:15133948 | pubmed:affiliation | Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA. | lld:pubmed |
| pubmed-article:15133948 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15133948 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15133948 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
