| pubmed-article:1512634 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0016410 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0021826 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C0439185 | lld:lifeskim |
| pubmed-article:1512634 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:1512634 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1512634 | pubmed:dateCreated | 1992-10-1 | lld:pubmed |
| pubmed-article:1512634 | pubmed:abstractText | The intestinal absorption and in vivo kinetics of (6S)-[3H]-5-methyl-tetrahydrofolate (5-methyl-H4folate), (6S)-[3H]-5-formyl-H4folate and [3H]folic acid were investigated to determine whether inherent differences exist in the overall bioavailability of these folates in rats. Adult rats (n = 9 per group) were given an intragastric dose of the appropriate folate (50 pmol/100 g body wt) in 50 mmol/L ascorbate (pH 7). Each compound underwent nearly complete absorption within 8 h, and there was no significant difference in the excretion kinetics in relation to the form of folate administered. A biphasic pattern of excretion was observed over the following 8 d. Both urine and feces were important excretory routes. The rapid phase of total isotopic excretion (urinary and fecal) exhibited a half time (t1/2) of 0.11-0.12 d, whereas the t1/2 of the slower phase was 13.4-15.9 d. Isotopic distributions and the pattern of labeled folates in urine and tissues were similar regardless of the form administered. These results indicate that the bioavailability of orally administered folic acid, 5-methyl-H4folate and 5-formyl-H4folate is equivalent in rats under the conditions of this study. | lld:pubmed |
| pubmed-article:1512634 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1512634 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1512634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1512634 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1512634 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1512634 | pubmed:issn | 0022-3166 | lld:pubmed |
| pubmed-article:1512634 | pubmed:author | pubmed-author:BhandariS DSD | lld:pubmed |
| pubmed-article:1512634 | pubmed:author | pubmed-author:GregoryJ... | lld:pubmed |
| pubmed-article:1512634 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1512634 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:1512634 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1512634 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1512634 | pubmed:pagination | 1847-54 | lld:pubmed |
| pubmed-article:1512634 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:meshHeading | pubmed-meshheading:1512634-... | lld:pubmed |
| pubmed-article:1512634 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1512634 | pubmed:articleTitle | Folic acid, 5-methyl-tetrahydrofolate and 5-formyl-tetrahydrofolate exhibit equivalent intestinal absorption, metabolism and in vivo kinetics in rats. | lld:pubmed |
| pubmed-article:1512634 | pubmed:affiliation | Food Science and Human Nutrition Department, University of Florida, Gainesville 32611-0370. | lld:pubmed |
| pubmed-article:1512634 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1512634 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1512634 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
