| pubmed-article:15125940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0002482 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C1416548 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C1552603 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C1706202 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15125940 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:15125940 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15125940 | pubmed:dateCreated | 2004-5-5 | lld:pubmed |
| pubmed-article:15125940 | pubmed:abstractText | The search for novel, potent Kv1.5 blockers based on an anthranilic amide scaffold employing a pharmacophore-based virtual screening approach is described. The synthesis and structure-activity relationships (SAR) with respect to inhibition of the Kv1.5 channel are discussed. The most potent compounds display sub-micromolar inhibition of Kv1.5 and no significant effect on the HERG channel. In addition, good oral bioavailability is demonstrated for compound 3i in rats. | lld:pubmed |
| pubmed-article:15125940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15125940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15125940 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15125940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15125940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15125940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15125940 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15125940 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:HemmerleHorst... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:BrendelJoachi... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:PeukertStefan... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:KleemannHeinz... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:StrübingCarst... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:PirardBernard... | lld:pubmed |
| pubmed-article:15125940 | pubmed:author | pubmed-author:BöhmeThomasT | lld:pubmed |
| pubmed-article:15125940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15125940 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15125940 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15125940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15125940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15125940 | pubmed:pagination | 2823-7 | lld:pubmed |
| pubmed-article:15125940 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
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| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
| pubmed-article:15125940 | pubmed:meshHeading | pubmed-meshheading:15125940... | lld:pubmed |
| pubmed-article:15125940 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15125940 | pubmed:articleTitle | Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel. | lld:pubmed |
| pubmed-article:15125940 | pubmed:affiliation | Aventis Pharma Deutschland GmbH, Medicinal Chemistry and DG Cardiovascular, D-65926 Frankfurt, Germany. stefan.peukert@aventis.com | lld:pubmed |
| pubmed-article:15125940 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:15125940 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15125940 | lld:pubmed |
