Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15122578rdf:typepubmed:Citationlld:pubmed
pubmed-article:15122578lifeskim:mentionsumls-concept:C0001483lld:lifeskim
pubmed-article:15122578lifeskim:mentionsumls-concept:C0017296lld:lifeskim
pubmed-article:15122578lifeskim:mentionsumls-concept:C0919437lld:lifeskim
pubmed-article:15122578lifeskim:mentionsumls-concept:C0205349lld:lifeskim
pubmed-article:15122578pubmed:issue4lld:pubmed
pubmed-article:15122578pubmed:dateCreated2004-5-3lld:pubmed
pubmed-article:15122578pubmed:abstractTextAdenoviral gene therapy is an exciting novel approach for treating cancers resistant to currently available therapies. However, currently there is little evidence supporting significant clinical benefits with replication-incompetent adenoviruses. Recent data suggest that expression of the primary receptor, the coxsackie-adenovirus receptor (CAR), may be highly variable on tumor cells, resulting in resistance to infection. Consequently, various strategies have been evaluated to modify adenovirus tropism in order to circumvent CAR deficiency, including retargeting complexes or genetic capsid modifications. To improve tumor penetration and local amplification on the antitumor effect, selectively oncolytic agents, i.e., conditionally replicating adenoviruses, have been constructed. Infection of tumor cells results in replication, oncolysis and subsequent release of the virus progeny. Normal tissue is spared due to lack of replication. This review focuses on the various modifications that have been investigated for improving the antitumor effect of adenoviral gene therapy.lld:pubmed
pubmed-article:15122578pubmed:languageenglld:pubmed
pubmed-article:15122578pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15122578pubmed:citationSubsetIMlld:pubmed
pubmed-article:15122578pubmed:statusMEDLINElld:pubmed
pubmed-article:15122578pubmed:monthJullld:pubmed
pubmed-article:15122578pubmed:issn0020-7136lld:pubmed
pubmed-article:15122578pubmed:authorpubmed-author:KanervaAnnaAlld:pubmed
pubmed-article:15122578pubmed:authorpubmed-author:HemminkiAksel...lld:pubmed
pubmed-article:15122578pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
pubmed-article:15122578pubmed:issnTypePrintlld:pubmed
pubmed-article:15122578pubmed:day1lld:pubmed
pubmed-article:15122578pubmed:volume110lld:pubmed
pubmed-article:15122578pubmed:ownerNLMlld:pubmed
pubmed-article:15122578pubmed:authorsCompleteYlld:pubmed
pubmed-article:15122578pubmed:pagination475-80lld:pubmed
pubmed-article:15122578pubmed:dateRevised2007-7-24lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:meshHeadingpubmed-meshheading:15122578...lld:pubmed
pubmed-article:15122578pubmed:year2004lld:pubmed
pubmed-article:15122578pubmed:articleTitleModified adenoviruses for cancer gene therapy.lld:pubmed
pubmed-article:15122578pubmed:affiliationCancer Gene Therapy Group, Rational Drug Design, Biomedicum Helsinki, University of Helsinki, Finland.lld:pubmed
pubmed-article:15122578pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15122578pubmed:publicationTypeReviewlld:pubmed
pubmed-article:15122578pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15122578lld:pubmed