| pubmed-article:15120462 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15120462 | lifeskim:mentions | umls-concept:C0697105 | lld:lifeskim |
| pubmed-article:15120462 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15120462 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15120462 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15120462 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:15120462 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:15120462 | pubmed:dateCreated | 2004-5-3 | lld:pubmed |
| pubmed-article:15120462 | pubmed:abstractText | In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (family: Leguminosae) have been employed clinically for centuries for their anti-inflammatory, antiulcer, expectorant, antimicrobial and anxiolytic activities. The present study was undertaken to investigate the effects of Glycyrrhiza glabra (popularly known as liquorice) on learning and memory in mice. Elevated plus-maze and passive avoidance paradigm were employed to test learning and memory. Three doses (75, 150 and 300 mg/kg p.o.) of aqueous extract of Glycyrrhiza glabra were administered for 7 successive days in separate groups of animals. The dose of 150 mg/kg of the aqueous extract of liquorice significantly improved learning and memory of mice. Furthermore, this dose significantly reversed the amnesia induced by diazepam (1 mg/kg i.p.) and scopolamine (0.4 mg/kg i.p.). Anti-inflammatory and antioxidant properties of liquorice may be contributing favorably to the memory enhancement effect. Since scopolamine-induced amnesia was reversed by liquorice, it is possible that the beneficial effect on learning and memory was due to facilitation of cholinergic-transmission in mouse brain. However, further studies are necessitated to identify the exact mechanism of action. In the present investigation, Glycyrrhiza glabra has shown promise as a memory enhancing agent in all the laboratory models employed. | lld:pubmed |
| pubmed-article:15120462 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15120462 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15120462 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15120462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15120462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15120462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15120462 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15120462 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15120462 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15120462 | pubmed:issn | 0378-8741 | lld:pubmed |
| pubmed-article:15120462 | pubmed:author | pubmed-author:KulkarniS KSK | lld:pubmed |
| pubmed-article:15120462 | pubmed:author | pubmed-author:ParleMilindM | lld:pubmed |
| pubmed-article:15120462 | pubmed:author | pubmed-author:DhingraDinesh... | lld:pubmed |
| pubmed-article:15120462 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15120462 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:15120462 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15120462 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15120462 | pubmed:pagination | 361-5 | lld:pubmed |
| pubmed-article:15120462 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15120462 | pubmed:meshHeading | pubmed-meshheading:15120462... | lld:pubmed |
| pubmed-article:15120462 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15120462 | pubmed:articleTitle | Memory enhancing activity of Glycyrrhiza glabra in mice. | lld:pubmed |
| pubmed-article:15120462 | pubmed:affiliation | Pharmacology Division, Department of Pharmaceutical Sciences, P.O. Box 38, Guru Jambheshwar University, Hisar 125001, Haryana, India. din_dhingra@yahoo.com | lld:pubmed |
| pubmed-article:15120462 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15120462 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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