| pubmed-article:1511846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C1522460 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0032824 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:1511846 | lifeskim:mentions | umls-concept:C0167029 | lld:lifeskim |
| pubmed-article:1511846 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1511846 | pubmed:dateCreated | 1992-9-30 | lld:pubmed |
| pubmed-article:1511846 | pubmed:abstractText | 1. In rat thoracic aorta, LP-805 (0.1-10 microM) caused the marked reduction of NE-induced maximum response and relaxed the low K+ (less than 35.9 mM)-induced contraction, in a concentration-dependent manner, but failed to relax the high K+ (65.9 mM)-induced contraction. 2. Glibenclamide (0.3-1 microM) caused a parallel shift of concentration-response curve produced by LP-805 for 25.9 mM K(+)-induced contraction and prevented the LP-805-induced reduction in maximum response evoked by NE in a concentration-dependent manner. 3. Glibenclamide (10 microM) prevented the LP-805 (10 microM)-induced decrease in cytosolic Ca2+ levels which was increased by 1 microM NE or 25.9 mM K+. 4. LP-805 (10 microM) increased basal 86Rb efflux, which was completely inhibited by 10 microM glibenclamide. 5. The results suggest that LP-805 causes a vasorelaxation as a consequence of the decrease in cytosolic Ca2+ levels due to the increase in K+ efflux via opening ATP-dependent K+ channels. | lld:pubmed |
| pubmed-article:1511846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1511846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1511846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1511846 | pubmed:month | May | lld:pubmed |
| pubmed-article:1511846 | pubmed:issn | 0306-3623 | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:MorimotoTT | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:TakayanagiII | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:NakajimaNN | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:YamazakiKK | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:TsujitaniMM | lld:pubmed |
| pubmed-article:1511846 | pubmed:author | pubmed-author:KishiiKK | lld:pubmed |
| pubmed-article:1511846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1511846 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:1511846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1511846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1511846 | pubmed:pagination | 347-53 | lld:pubmed |
| pubmed-article:1511846 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1511846 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1511846 | pubmed:articleTitle | Effects of LP-805, a novel vasorelaxant agent, a potassium channel opener, on rat thoracic aorta. | lld:pubmed |
| pubmed-article:1511846 | pubmed:affiliation | POLA Pharmaceutical R&D Laboratory, Yokohama, Japan. | lld:pubmed |
| pubmed-article:1511846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1511846 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1511846 | lld:pubmed |
