Linked Life Data

15113609

Source:http://linkedlifedata.com/resource/pubmed/id/15113609

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pubmed-article:15113609pubmed:dateCreated2004-4-28lld:pubmed
pubmed-article:15113609pubmed:abstractTextIn order to develop the desirable drug release patterns such as no lag time and exact zero-order release rate, gentamicin sulfate (GS)-loaded poly(D,L-lactide-co-glycolide) (PLGA) discs containing lactide monomer (LM) or glycolide monomer (GM) were prepared. LM or GM was applied for the controlling drug release pattern due to its non-toxic and biodegradable nature. Water absorption, mass loss, pH change, and morphology of discs were examined to study the effect of LM or GM addition. GS release showed near zero-order profile in the GS-loaded polymeric discs prepared in the presence of LM or GM (10%). The channel of GS-loaded PLGA containing LM or GM was formed by the dissolution of LM or GM. Water uptake of disc increased till 21 days from the beginning of the test. The pH variations of media declined in the same manner with the result of mass loss. The antibiosis of GS was also confirmed by bacterial inhibition zone test using the prepared polymeric discs. From these results, we expected that the polymeric discs containing LM or GM would be a good dosage form as a topically implantable device which can get rid of lag period from PLGA matrix.lld:pubmed
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pubmed-article:15113609pubmed:authorpubmed-author:KimYong SikYSlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:KhangGilsonGlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:LeeHai BangHBlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:KimJong MinJMlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:KimMoon SukMSlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:ChoSun HangSHlld:pubmed
pubmed-article:15113609pubmed:authorpubmed-author:YooJe YoungJYlld:pubmed
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pubmed-article:15113609pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15113609pubmed:year2004lld:pubmed
pubmed-article:15113609pubmed:articleTitleEffect of lactide/glycolide monomers on release behaviors of gentamicin sulfate-loaded PLGA discs.lld:pubmed
pubmed-article:15113609pubmed:affiliationDepartment of Advanced Organic Materials Engineering, Chonbuk National University, 664-14 Dukjin, Jeonju 561-756, Republic of Korea.lld:pubmed
pubmed-article:15113609pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15113609pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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