| pubmed-article:15110768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15110768 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15110768 | lifeskim:mentions | umls-concept:C0029431 | lld:lifeskim |
| pubmed-article:15110768 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:15110768 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15110768 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15110768 | pubmed:dateCreated | 2004-4-27 | lld:pubmed |
| pubmed-article:15110768 | pubmed:abstractText | Mouse marrow, which contains osteoblast and osteoclast precursors, was grown in the presence of calcitriol and/or basic fibroblast growth factor (FGF-2). RAW 264.7 cells were differentiated into osteoclast-like cells in the presence of receptor activator of NF-kappaB-Ligand (RANK-L) and/or FGF-2. FGF-2 alone supported osteoclastogenesis in mouse marrow cultures, but not by RAW 264.7 cells alone. Although FGF-2 supported low levels of osteoclastogenesis in mouse marrow cultures, it strongly inhibited the high levels of osteoclastogenesis triggered by calcitriol. Adding excess recombinant-RANK-L to the cultures did not relieve this inhibition. After mouse marrow osteoclasts were differentiated, FGF-2 dose-dependently inhibited bone resorptive activity. FGF-2 increased the tendency of RAW 264.7 osteoclast-like cells to fuse into very large giant cells and induced reorganizations of the actin cytoskeleton in mature, RANK-L-induced RAW 264.7 osteoclast-like cells. These results suggest that FGF-2 has both direct and indirect effects on osteoclast formation and bone resorption. | lld:pubmed |
| pubmed-article:15110768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15110768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15110768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15110768 | pubmed:month | May | lld:pubmed |
| pubmed-article:15110768 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15110768 | pubmed:author | pubmed-author:ZuoJianJ | lld:pubmed |
| pubmed-article:15110768 | pubmed:author | pubmed-author:DolceCalogero... | lld:pubmed |
| pubmed-article:15110768 | pubmed:author | pubmed-author:JiangJinJ | lld:pubmed |
| pubmed-article:15110768 | pubmed:author | pubmed-author:HollidayL... | lld:pubmed |
| pubmed-article:15110768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15110768 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:15110768 | pubmed:volume | 318 | lld:pubmed |
| pubmed-article:15110768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15110768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15110768 | pubmed:pagination | 162-7 | lld:pubmed |
| pubmed-article:15110768 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15110768 | pubmed:meshHeading | pubmed-meshheading:15110768... | lld:pubmed |
| pubmed-article:15110768 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15110768 | pubmed:articleTitle | Effects of basic fibroblast growth factor on osteoclasts and osteoclast-like cells. | lld:pubmed |
| pubmed-article:15110768 | pubmed:affiliation | Department of Orthodontics, University of Florida College of Dentistry, USA. | lld:pubmed |
| pubmed-article:15110768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15110768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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