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| pubmed-article:1511008 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:1511008 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:1511008 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1511008 | pubmed:dateCreated | 1992-9-30 | lld:pubmed |
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| pubmed-article:1511008 | pubmed:abstractText | We have isolated a 2228 bp cDNA clone encoding a chicken homologue of the human Bcl-2 oncoprotein by low-stringency hybridization screening of a lambda gt10 cDNA library derived from a chicken B-cell lymphoma. DNA sequence analysis of this cDNA revealed an open reading frame predicting a polypeptide of 232 amino acids and an M(r) of 25,839. The predicted protein is highly homologous to the human (73%) and mouse (70%) Bcl-2 proteins, and contains a hydrophobic stretch of amino acids within its carboxyl-end (213-229) consistent with an integral membrane protein. Areas of very high sequence homology shared by all three Bcl-2 proteins at the NH2-terminus (amino acids 1-33) and within the last 150 amino acids of these proteins suggest the presence of at least two evolutionarily conserved domains within the family of Bcl-2 proteins that may be important either for their targeting to mitochondria or their ability to block programmed cell death. | lld:pubmed |
| pubmed-article:1511008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1511008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1511008 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1511008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1511008 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1511008 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:1511008 | pubmed:author | pubmed-author:ReedJ CJC | lld:pubmed |
| pubmed-article:1511008 | pubmed:author | pubmed-author:TanakaSS | lld:pubmed |
| pubmed-article:1511008 | pubmed:author | pubmed-author:LouieD CDC | lld:pubmed |
| pubmed-article:1511008 | pubmed:author | pubmed-author:Cazals-HatemD... | lld:pubmed |
| pubmed-article:1511008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1511008 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:1511008 | pubmed:volume | 1132 | lld:pubmed |
| pubmed-article:1511008 | pubmed:geneSymbol | bcl-2 | lld:pubmed |
| pubmed-article:1511008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1511008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1511008 | pubmed:pagination | 109-13 | lld:pubmed |
| pubmed-article:1511008 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:1511008 | pubmed:meshHeading | pubmed-meshheading:1511008-... | lld:pubmed |
| pubmed-article:1511008 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1511008 | pubmed:articleTitle | Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein. | lld:pubmed |
| pubmed-article:1511008 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia. | lld:pubmed |
| pubmed-article:1511008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1511008 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1511008 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:396282 | entrezgene:pubmed | pubmed-article:1511008 | lld:entrezgene |
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