Linked Life Data

15108330

Source:http://linkedlifedata.com/resource/pubmed/id/15108330

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15108330rdf:typepubmed:Citationlld:pubmed
pubmed-article:15108330lifeskim:mentionsumls-concept:C0025914lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0021270lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C1515657lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0023884lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0012854lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C1511790lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0392747lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:15108330lifeskim:mentionsumls-concept:C0443172lld:lifeskim
pubmed-article:15108330pubmed:issue1lld:pubmed
pubmed-article:15108330pubmed:dateCreated2004-4-26lld:pubmed
pubmed-article:15108330pubmed:abstractTextThe present work describes the use of the infant (4-wk-old) mouse as an animal model for the study of DNA damage-induced G(1) checkpoint response, changes in p53 protein levels, and multiple gene expression changes after DNA damage has been induced in the liver. Hepatocytes in the infant B6C3F1 mouse had a proliferation index that was 27 times greater than that of the 12-wk-old B6C3F1 mouse (57.4 vs. 2.1%, respectively). Eight hours after infant mice were exposed to the DNA damaging agents bleomycin (100 mg/kg, i.p.) or 10 Gy of whole body gamma irradiation, the G(1)/S ratio significantly increased from 21 (control) to 66 and 75, respectively, because of the induction of the G(1)/S checkpoint response. One hour after whole body irradiation of infant mice the levels of the p53 protein, phosphoserine 18-p53 and phosphoserine 23-p53 increased dramatically and tended to peak at 1 h in the liver, whereas the p21(WAF1) protein increased more slowly and tended to peak at 2 h after irradiation. The mRNA expression of the p53-response genes p21, murine double minute clone 2 (mdm2), and cyclin G was increased at 2 h after irradiation but was decreased by 8 h postirradiation, relative to the 2-h time-point. The expression of insulin-like growth factor binding protein-1 (IGFBP-1) and growth-regulated oncogene 1 (GRO1) increased at 2 and 8 h postirradiation. This work characterizes various parameters in the infant mouse, thus validating the use of this model to study in vivo DNA damage-induced cell-cycle-related changes.lld:pubmed
pubmed-article:15108330pubmed:languageenglld:pubmed
pubmed-article:15108330pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:citationSubsetIMlld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15108330pubmed:statusMEDLINElld:pubmed
pubmed-article:15108330pubmed:monthMaylld:pubmed
pubmed-article:15108330pubmed:issn0899-1987lld:pubmed
pubmed-article:15108330pubmed:authorpubmed-author:TuckS MSMlld:pubmed
pubmed-article:15108330pubmed:authorpubmed-author:ReynoldsRanda...lld:pubmed
pubmed-article:15108330pubmed:authorpubmed-author:WitherspoonSa...lld:pubmed
pubmed-article:15108330pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
pubmed-article:15108330pubmed:issnTypePrintlld:pubmed
pubmed-article:15108330pubmed:volume40lld:pubmed
pubmed-article:15108330pubmed:ownerNLMlld:pubmed
pubmed-article:15108330pubmed:authorsCompleteYlld:pubmed
pubmed-article:15108330pubmed:pagination62-72lld:pubmed
pubmed-article:15108330pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:meshHeadingpubmed-meshheading:15108330...lld:pubmed
pubmed-article:15108330pubmed:year2004lld:pubmed
pubmed-article:15108330pubmed:articleTitleThe infant mouse as a in vivo model for the detection and study of DNA damage-induced changes in the liver.lld:pubmed
pubmed-article:15108330pubmed:affiliationDepartment of Comparative Biomedical Sciences, North Carolina State University, Raleigh, North Carolina, USA.lld:pubmed
pubmed-article:15108330pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15108330lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15108330lld:pubmed