| pubmed-article:1510415 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0162714 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:1510415 | lifeskim:mentions | umls-concept:C0453882 | lld:lifeskim |
| pubmed-article:1510415 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1510415 | pubmed:dateCreated | 1992-9-22 | lld:pubmed |
| pubmed-article:1510415 | pubmed:abstractText | C2 symmetry-based human immunodeficiency virus (HIV) protease inhibitors were examined in vitro as single agents or in combination with 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine for activity against HIV type 1 (HIV-1). Ten C2 symmetry-based or pseudo-C2 symmetry-based HIV protease inhibitors were active against a laboratory strain (HIV-1IIIB) in the HIV-1 cytopathic effect inhibition assay. Three inhibitors, A75925, A76928, and A77003, selected to represent a range of aqueous solubility and antiviral activity, were active against four different HIV-1 strains tested. These three inhibitors exhibited a significant inhibition of the cytopathic effect of HIV-1 against the CD4+ ATH8 cell line, with 90% inhibitory concentrations ranging from 0.1 to 4 microM. Cellular toxicity was negligible at up to 20 microM. Furthermore, they completely inhibited the replication of monocytotropic strain HIV-1Ba-L in purified monocytes and macrophages at 0.75 to 2 microM. Potent inhibitory activity against a primary HIV-1 isolate and an AZT-resistant HIV-1 variant was also observed for all three inhibitors in phytohemagglutinin-activated peripheral blood mononuclear cells. When these three HIV protease inhibitors and AZT or 2',3'-dideoxyinosine were used in combinations against a primary HIV isolate in phytohemagglutinin-activated peripheral blood mononuclear cells and the results were analyzed with the COMBO program package, their antiviral activities were identified to be synergistic in some cases and additive in others. The present data warrant further investigations of these compounds as potential antiviral agents for the therapy of HIV infections. | lld:pubmed |
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| pubmed-article:1510415 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1510415 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1510415 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1510415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1510415 | pubmed:month | May | lld:pubmed |
| pubmed-article:1510415 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:EricksonJJ | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:MitsuyaHH | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:WeinsteinJ... | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:ShirasakaTT | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:PlattnerJ JJJ | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:KageyamaSS | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:KempfD JDJ | lld:pubmed |
| pubmed-article:1510415 | pubmed:author | pubmed-author:NorbeckD WDW | lld:pubmed |
| pubmed-article:1510415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1510415 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:1510415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1510415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1510415 | pubmed:pagination | 926-33 | lld:pubmed |
| pubmed-article:1510415 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1510415 | pubmed:meshHeading | pubmed-meshheading:1510415-... | lld:pubmed |
| pubmed-article:1510415 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1510415 | pubmed:articleTitle | In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations. | lld:pubmed |
| pubmed-article:1510415 | pubmed:affiliation | Experimental Retrovirology Section, National Cancer Institute, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1510415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1510415 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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