| pubmed-article:15102857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C0037663 | lld:lifeskim |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C0969119 | lld:lifeskim |
| pubmed-article:15102857 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15102857 | pubmed:issue | 31 | lld:pubmed |
| pubmed-article:15102857 | pubmed:dateCreated | 2004-7-26 | lld:pubmed |
| pubmed-article:15102857 | pubmed:abstractText | We demonstrate here that growth hormone (GH) stimulates the activation of RhoA and its substrate Rho kinase (ROCK) in NIH-3T3 cells. GH-stimulated formation of GTP-bound RhoA requires JAK2-dependent dissociation of RhoA from its negative regulator p190 RhoGAP. Inactivation of RhoA does not affect GH-stimulated JAK2 tyrosine phosphorylation nor p44/42 MAPK activity. However, RhoA and ROCK activities are required for GH-stimulated, Stat5-mediated transcription. RhoA-dependent enhancement of GH-stimulated, Stat5-mediated transcription is due to repression of histone deacetylase 6 activity recruited by transcription cofactor p300 that negatively regulates GH-stimulated, Stat5-mediated transcription. We also demonstrate that RhoA is the pivot for cAMP-dependent protein kinase inhibition of GH-stimulated, Stat5-mediated transcription as a consequence of cAMP-dependent protein kinase inactivation of RhoA through serine residue 188 of RhoA. We have therefore provided a novel mechanism by which a Ras-like small GTPase, RhoA, can regulate Stat5-mediated transcription. | lld:pubmed |
| pubmed-article:15102857 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15102857 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15102857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15102857 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15102857 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15102857 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:15102857 | pubmed:author | pubmed-author:LobiePeter... | lld:pubmed |
| pubmed-article:15102857 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15102857 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15102857 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15102857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15102857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15102857 | pubmed:pagination | 32737-50 | lld:pubmed |
| pubmed-article:15102857 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15102857 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15102857 | pubmed:articleTitle | RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription. | lld:pubmed |
| pubmed-article:15102857 | pubmed:affiliation | Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore. | lld:pubmed |
| pubmed-article:15102857 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15102857 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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