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pubmed-article:15100467pubmed:issue6lld:pubmed
pubmed-article:15100467pubmed:dateCreated2004-4-21lld:pubmed
pubmed-article:15100467pubmed:abstractTextHost-guest complexes between nucleobases or nucleosides and beta-cyclodextrin can be observed by electrospray ionization mass spectrometry (ESI-MS) and their relative abundances appear to correlate with the condensed-phase binding order. Using Fourier transform ion cyclotron resonance mass spectrometry, the extent of the interactions between the host oligosaccharide and guest species have also been examined for permethylated beta-cyclodextrin : adenine/deoxyadenosine and permethylated maltoheptaose : adenine/deoxyadenosine using gas-phase exchange reactions with the gaseous amines, n-propylamine and ethylenediamine. The ease of guest exchange in the gas-phase follows the order : deoxyadenosine > adenine > deoxycytidine > cytosine, which is in contrast to their relative binding order in solution. Collision-induced dissociation (CID) has been used to probe the fragmentation behavior of oligosaccharide : nucleobase/nucleoside complexes. Under these conditions the inclusion complexes either (a) dissociate, (b) result in cleavage of the host oligosaccharide or (c) result in cleavage of the guest molecule. This study has shown that the preferred dissociation pathway of these complexes depends on the structures of both the cyclodextrin and guest molecule.lld:pubmed
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pubmed-article:15100467pubmed:authorpubmed-author:LebrillaCarli...lld:pubmed
pubmed-article:15100467pubmed:authorpubmed-author:VrkicAna KAKlld:pubmed
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pubmed-article:15100467pubmed:volume9lld:pubmed
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pubmed-article:15100467pubmed:pagination563-77lld:pubmed
pubmed-article:15100467pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15100467pubmed:articleTitleUnusual covalent bond-breaking reactions of beta-cyclodextrin inclusion complexes of nucleobases/nucleosides and related guest molecules.lld:pubmed
pubmed-article:15100467pubmed:affiliationSchool of Chemistry, University of Melbourne, Victoria, Australia 3010.lld:pubmed
pubmed-article:15100467pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15100467pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed