| pubmed-article:15099700 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C2004491 | lld:lifeskim |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C0019134 | lld:lifeskim |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C0028959 | lld:lifeskim |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:15099700 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:15099700 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15099700 | pubmed:dateCreated | 2004-4-21 | lld:pubmed |
| pubmed-article:15099700 | pubmed:abstractText | Injury to the central nervous system causes glial reactions, which eventually lead to the formation of a glial scar and inhibit axonal regeneration. The present study aimed to reduce the extent of glial scar formation in injured cerebral cortex using heparin hexasaccharide (6-mer) and octasaccharide (8-mer). A single injection of 20 microl of heparin 6-mer or heparin 8-mer (10mg/ml), native heparin (10mg/ml), or saline vehicle was given into the wound cavity just after cryo-injury in the cerebral cortex. In saline-injected control rats, strong chondroitin sulfate-A (CS-A) immunoreactivity using 2H6 antibody was observed around the injured site. Double labeling using an antibody against glial fibrillary acidic protein, a glial marker, further demonstrated that CS-A immunoreactivity was mainly expressed on the reactive astrocytes at the glial scar, indicating that CS-A immunohistochemistry is useful for evaluating glial scar formation. Quantitative morphometrical analysis revealed that the area of CS-A immunoreactivity was significantly decreased by 53% in heparin-6-mer-injected animals and 44% in heparin-8-mer-injected ones 6 days after the injury, but native heparin had no effect on CS-A-immunoreactive areas. Both heparin oligosaccharides also attenuated the intensity of CS-A immunoreactivity in the reactive astrocytes and caused astrocytic cellular processes to be less branched. These results demonstrate that a single injection of heparin oligosaccharides attenuates glial scar formation, indicating that heparin oligosaccharides may be applicable to many fibrotic diseases and restore functional integrity. | lld:pubmed |
| pubmed-article:15099700 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15099700 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15099700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15099700 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15099700 | pubmed:month | May | lld:pubmed |
| pubmed-article:15099700 | pubmed:issn | 0168-0102 | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:HaraSaburoS | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:KameiKaekoK | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:TakanoRyoR | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:MiyataSeijiS | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:KariyaYutakaY | lld:pubmed |
| pubmed-article:15099700 | pubmed:author | pubmed-author:HayashiNoriko... | lld:pubmed |
| pubmed-article:15099700 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15099700 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:15099700 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15099700 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15099700 | pubmed:pagination | 19-27 | lld:pubmed |
| pubmed-article:15099700 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
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| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:meshHeading | pubmed-meshheading:15099700... | lld:pubmed |
| pubmed-article:15099700 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15099700 | pubmed:articleTitle | Attenuation of glial scar formation in the injured rat brain by heparin oligosaccharides. | lld:pubmed |
| pubmed-article:15099700 | pubmed:affiliation | Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. | lld:pubmed |
| pubmed-article:15099700 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15099700 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15099700 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
