| pubmed-article:15096540 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15096540 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15096540 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15096540 | pubmed:dateCreated | 2004-4-20 | lld:pubmed |
| pubmed-article:15096540 | pubmed:abstractText | The T-box transcription factor T-bet is known to control lineage commitment and interferon-gamma production by T helper 1 (Th1) CD4 lymphocytes. We report here that T-bet is essential for development of CD8 lymphocyte-dependent autoimmune diabetes (type 1 diabetes [T1D]) in the rat insulin promoter-lymphocytic choriomeningitis virus (LCMV) transgenic model for virally induced T1D. In the absence of T-bet, autoaggressive (anti-LCMV) CD8 lymphocytes were reduced in number and produced less IFN-gamma, but increased IL-2 compared with controls. Further analysis showed that T-bet intrinsically controls the generation, but not apoptosis, maintenance, or secondary expansion of antiviral effector/memory CD8 lymphocytes. This observation points toward a therapeutic opportunity for the treatment of T1D and other autoimmune disorders. | lld:pubmed |
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| pubmed-article:15096540 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15096540 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15096540 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15096540 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15096540 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15096540 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:15096540 | pubmed:author | pubmed-author:GlimcherLauri... | lld:pubmed |
| pubmed-article:15096540 | pubmed:author | pubmed-author:RodrigoEvelyn... | lld:pubmed |
| pubmed-article:15096540 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:15096540 | pubmed:author | pubmed-author:JuedesAmy EAE | lld:pubmed |
| pubmed-article:15096540 | pubmed:author | pubmed-author:TogherLisaL | lld:pubmed |
| pubmed-article:15096540 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15096540 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:15096540 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:15096540 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15096540 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15096540 | pubmed:pagination | 1153-62 | lld:pubmed |
| pubmed-article:15096540 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
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| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:meshHeading | pubmed-meshheading:15096540... | lld:pubmed |
| pubmed-article:15096540 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15096540 | pubmed:articleTitle | T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. | lld:pubmed |
| pubmed-article:15096540 | pubmed:affiliation | Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr., San Diego, CA 92121, USA. | lld:pubmed |
| pubmed-article:15096540 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15096540 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
