| pubmed-article:15096185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C1167250 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0023745 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0596761 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0868945 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15096185 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:15096185 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15096185 | pubmed:dateCreated | 2004-4-20 | lld:pubmed |
| pubmed-article:15096185 | pubmed:abstractText | We previously developed a transgenic mouse line into which a rabbit protein kinase Calpha (PKCalpha) gene fused to a human CD2 promoter/enhancer was introduced, and we found that immunosenescence was facilitated in these transgenic mice. In this study, we found that along with age-dependent increase in the level of protein expression of PKCalpha and its translocation to the membrane, activated T cells became less sensitive to apoptosis-inducing anti-Fas antibody. The capacity of T cells to express Fas antigen on their surfaces in response to anti-CD3 and interleukin-2 was impaired in PKCalpha-transgenic mice of relatively advanced age, although background Fas expression levels on T cells from those mice were high. We then found that out of proportion to a high level of cell surface Fas expression the density of cholera toxin B (CTx)-binding raft elements decreased in PKCalpha-transgenic mice of relatively advanced age and to a lesser extent in normal mice of advanced age. Correspondingly, the expression level of raft-associating Lck was decreased in these mice. These findings suggest for the first time that immunosenescence of T cells involves a decrease in density of cell surface CTx-binding raft elements, which might underlie a deterioration in T-cell signal pathway for either cell death or cell activation. | lld:pubmed |
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| pubmed-article:15096185 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15096185 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15096185 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15096185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15096185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15096185 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15096185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15096185 | pubmed:month | May | lld:pubmed |
| pubmed-article:15096185 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:15096185 | pubmed:author | pubmed-author:NuM HMH | lld:pubmed |
| pubmed-article:15096185 | pubmed:author | pubmed-author:NakashimaIzum... | lld:pubmed |
| pubmed-article:15096185 | pubmed:author | pubmed-author:SuzukiHaruhik... | lld:pubmed |
| pubmed-article:15096185 | pubmed:author | pubmed-author:KawamotoYoshi... | lld:pubmed |
| pubmed-article:15096185 | pubmed:author | pubmed-author:YokoyamaToshi... | lld:pubmed |
| pubmed-article:15096185 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15096185 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:15096185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15096185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15096185 | pubmed:pagination | 64-71 | lld:pubmed |
| pubmed-article:15096185 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
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| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:meshHeading | pubmed-meshheading:15096185... | lld:pubmed |
| pubmed-article:15096185 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15096185 | pubmed:articleTitle | Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function. | lld:pubmed |
| pubmed-article:15096185 | pubmed:affiliation | Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. | lld:pubmed |
| pubmed-article:15096185 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15096185 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
