| pubmed-article:15084179 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15084179 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15084179 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:15084179 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:15084179 | lifeskim:mentions | umls-concept:C1415619 | lld:lifeskim |
| pubmed-article:15084179 | lifeskim:mentions | umls-concept:C0522536 | lld:lifeskim |
| pubmed-article:15084179 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15084179 | pubmed:dateCreated | 2004-4-15 | lld:pubmed |
| pubmed-article:15084179 | pubmed:abstractText | Tissue attenuates to injury by the effects of heme oxygenase (HO)-1. The induction of HO-1 expression is modulated by a (GT)(n) dinucleotide polymorphism in the promoter of the gene, of which increased activity is associated with short (S) (<or=27) repeats. We investigated the influence of this HO-1 gene polymorphism on renal transplant survival. DNA from 387 recipients and 384 donors was genotyped and we divided the HO-1 alleles into two subclasses, the S (<or=27 repeats) class and long (L) class (>27 repeats). Graft survival was associated with donor and not with recipient HO-1 gene polymorphism (log rank p = 0.005; hazard ratio 0.51, 95% CI 0.32-0.83). The beneficial effect of the donor HO-1 genotype was observed in grafts exposed to prolonged cold ischemia time and acute rejection. Patients who received a kidney from L-homozygotes lost their graft significantly more often to chronic allograft nephropathy (CAN) than carriers of S-alleles (p = 0.015). Multivariate analysis showed reduced risk for graft failure in kidneys with S-alleles in comparison to L-homozygotes (odds ratio 0.50, 95% CI 0.27-0.93, p = 0.03). Kidneys that are carriers of HO-1 S-allele are less vulnerable to tissue injury resulting in less CAN and better graft survival. | lld:pubmed |
| pubmed-article:15084179 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15084179 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15084179 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15084179 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15084179 | pubmed:month | May | lld:pubmed |
| pubmed-article:15084179 | pubmed:issn | 1600-6135 | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:ClaasFransF | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:WeimarWillemW | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:BaanCarlaC | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:PeetersAnnemi... | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:LemosFrancine... | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:UitterlindenA... | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:DoxiadisIlias... | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:IjzermansJanJ | lld:pubmed |
| pubmed-article:15084179 | pubmed:author | pubmed-author:RoodnatJokeJ | lld:pubmed |
| pubmed-article:15084179 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15084179 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:15084179 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15084179 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15084179 | pubmed:pagination | 811-8 | lld:pubmed |
| pubmed-article:15084179 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:meshHeading | pubmed-meshheading:15084179... | lld:pubmed |
| pubmed-article:15084179 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15084179 | pubmed:articleTitle | Fundamental role for HO-1 in the self-protection of renal allografts. | lld:pubmed |
| pubmed-article:15084179 | pubmed:affiliation | Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. c.c.baan@erasmusmc.nl | lld:pubmed |
| pubmed-article:15084179 | pubmed:publicationType | Journal Article | lld:pubmed |
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