| pubmed-article:15078871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C0032433 | lld:lifeskim |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C1159465 | lld:lifeskim |
| pubmed-article:15078871 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15078871 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:15078871 | pubmed:dateCreated | 2004-7-12 | lld:pubmed |
| pubmed-article:15078871 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:abstractText | Identification of the polyamine transporter gene will be useful for modulating polyamine accumulation in cells and should be a good target for controlling cell proliferation. Polyamine transport activity in mammalian cells is critical for accumulation of the polyamine analog methylglyoxal bis(guanylhydrazone) (MGBG) that induces apoptosis, although a gene responsible for transport activity has not been identified. Using a retroviral gene trap screen, we generated MGBG-resistant Chinese hamster ovary (CHO) cells to identify genes involved in polyamine transport activity. One gene identified by the method encodes TATA-binding protein-associated factor 7 (TAF7), which functions not only as one of the TAFs, but also a coactivator for c-Jun. TAF7-deficient cells had decreased capacity for polyamine uptake (20% of CHO cells), decreased AP-1 activation, as well as resistance to MGBG-induced apoptosis. Stable expression of TAF7 in TAF7-deficient cells restored transport activity (55% of CHO cells), AP-1 gene transactivation (100% of CHO cells), and sensitivity to MGBG-induced apoptosis. Overexpression of TAF7 in CHO cells did not increase transport activity, suggesting that TAF7 may be involved in the maintenance of basal activity. c-Jun NH2-terminal kinase inhibitors blocked MGBG-induced apoptosis without alteration of polyamine transport. Decreased TAF7 expression, by RNA interference, in androgen-independent human prostate cancer LN-CaP104-R1 cells resulted in lower polyamine transport activity (25% of control) and resistance to MGBG-induced growth arrest. Taken together, these results reveal a physiological function of TAF7 as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis. | lld:pubmed |
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| pubmed-article:15078871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15078871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15078871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15078871 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15078871 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:IgarashiKazue... | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:NishimuraKazu... | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:HiipakkaRicha... | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:LiaoShutsungS | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:FukuchiJunich... | lld:pubmed |
| pubmed-article:15078871 | pubmed:author | pubmed-author:KokontisJohn... | lld:pubmed |
| pubmed-article:15078871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15078871 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:15078871 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15078871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15078871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15078871 | pubmed:pagination | 29921-9 | lld:pubmed |
| pubmed-article:15078871 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15078871 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15078871 | pubmed:articleTitle | TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis. | lld:pubmed |
| pubmed-article:15078871 | pubmed:affiliation | Ben May Institute for Cancer Research and the Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA. | lld:pubmed |
| pubmed-article:15078871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15078871 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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