| pubmed-article:15076719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15076719 | lifeskim:mentions | umls-concept:C0035316 | lld:lifeskim |
| pubmed-article:15076719 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:15076719 | lifeskim:mentions | umls-concept:C0332464 | lld:lifeskim |
| pubmed-article:15076719 | lifeskim:mentions | umls-concept:C2827424 | lld:lifeskim |
| pubmed-article:15076719 | lifeskim:mentions | umls-concept:C1516312 | lld:lifeskim |
| pubmed-article:15076719 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15076719 | pubmed:dateCreated | 2004-4-12 | lld:pubmed |
| pubmed-article:15076719 | pubmed:abstractText | Following ischemia/reperfusion the death of retinal ganglion cells in adult Wistar rat retina continues for weeks. Using new, more stable caspase inhibitor, Q-VD-OPH we studied its neuroprotective effect on identifiable retinal ganglion cells after 75 min ischemia followed by reperfusion. Q-VD-OPH was injected intravitreally 48 h after ischemia/reperfusion. Retinal ganglion cells were labeled by intratectal injection of Fluorogold and cells were counted on flat mounted retinas. Retinal ganglion cells survival increased after 2 and 3 weeks of ischemia/reperfusion in Q-VD-OPH injected eyes. We studied apoptotic cell death by immunocytochemically labeling retina with cleaved Poly (ADP-ribose) polymerase (PARP). Labeling for cleaved PARP remained elevated in the ganglion cell layer and inner nuclear layer after 1,2and 3 weeks of ischemia/reperfusion. Administration of Q-VD-OPH significantly reduced the labeling for cleaved PARP in the retina and increased the survival of retinal ganglion cells. | lld:pubmed |
| pubmed-article:15076719 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15076719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076719 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15076719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076719 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15076719 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15076719 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:15076719 | pubmed:author | pubmed-author:SharmaSansar... | lld:pubmed |
| pubmed-article:15076719 | pubmed:author | pubmed-author:PatilKiranK | lld:pubmed |
| pubmed-article:15076719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15076719 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15076719 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15076719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15076719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15076719 | pubmed:pagination | 981-4 | lld:pubmed |
| pubmed-article:15076719 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:meshHeading | pubmed-meshheading:15076719... | lld:pubmed |
| pubmed-article:15076719 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15076719 | pubmed:articleTitle | Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia. | lld:pubmed |
| pubmed-article:15076719 | pubmed:affiliation | Department of Ophthalmology, Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA. | lld:pubmed |
| pubmed-article:15076719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15076719 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15076719 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15076719 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15076719 | lld:pubmed |
