| pubmed-article:15076711 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15076711 | lifeskim:mentions | umls-concept:C0012929 | lld:lifeskim |
| pubmed-article:15076711 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:15076711 | lifeskim:mentions | umls-concept:C1862941 | lld:lifeskim |
| pubmed-article:15076711 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:15076711 | lifeskim:mentions | umls-concept:C0597452 | lld:lifeskim |
| pubmed-article:15076711 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15076711 | pubmed:dateCreated | 2004-4-12 | lld:pubmed |
| pubmed-article:15076711 | pubmed:abstractText | One possible cause for the neuronal loss in sporadic amyotrophic lateral sclerosis (S-ALS) is an increase of free radicals, which may produce oxidative damage to susceptible biomolecules, which, in turn, can damage the mitochondrial DNA (mtDNA). Following laser microdissection of single motor neurons from paraffin-embedded autopsy tissue, we analyzed the presence of a common mtDNA deletion, the 5 kb common deletion (CD). Spinal cord neurons showed slightly higher CD detection rate in patients than controls (94% vs 75%). No significant differences were found between patients and controls for neurons derived from other motor or non-motor regions. A PCR assay of serial DNA dilutions (10-fold) showed no CD level differences between motor neurons in S-ALS and controls. These data suggest that neuronal death in S-ALS is not associated with significant accumulation of mtDNA deletions. | lld:pubmed |
| pubmed-article:15076711 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15076711 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076711 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15076711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15076711 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15076711 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15076711 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:MawrinChristi... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:KirchesElmarE | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:DietzmannKnut... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:WiedemannFalk... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:BogertsBernha... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:Schneider-Sto... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:SchildhausHan... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:VorwerkChrist... | lld:pubmed |
| pubmed-article:15076711 | pubmed:author | pubmed-author:KrauseGuidoG | lld:pubmed |
| pubmed-article:15076711 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15076711 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:15076711 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15076711 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15076711 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15076711 | pubmed:pagination | 939-43 | lld:pubmed |
| pubmed-article:15076711 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:meshHeading | pubmed-meshheading:15076711... | lld:pubmed |
| pubmed-article:15076711 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15076711 | pubmed:articleTitle | Single-cell analysis of mtDNA deletion levels in sporadic amyotrophic lateral sclerosis. | lld:pubmed |
| pubmed-article:15076711 | pubmed:affiliation | Department of Neuropathology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany. Christian.Marwin@Medizin.Uni-Magdeburg.de | lld:pubmed |
| pubmed-article:15076711 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15076711 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15076711 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15076711 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15076711 | lld:pubmed |
