| pubmed-article:15075794 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C0152013 | lld:lifeskim |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C0079664 | lld:lifeskim |
| pubmed-article:15075794 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:15075794 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15075794 | pubmed:dateCreated | 2004-4-12 | lld:pubmed |
| pubmed-article:15075794 | pubmed:abstractText | The non-coding variation in the second intron of the L-myc gene, generating an EcoRI polymorphism, is associated with lung cancer risk and prognosis. We carried out sequence analysis of the L-myc gene in lung adenocarcinoma (ADCA) patients to identify functional polymorphisms and identified a new single nucleotide polymorphism (SNP) in the third exon of the gene causing a Ser362Thr conservative amino acid change in the C-terminus of the encoded protein. This polymorphism showed significant linkage disequilibrium with the L-myc EcoRI polymorphism located at 1751 bp distance. Genotyping of the Ser362Thr SNP in 220 Italian ADCA patients and in 230 general population controls revealed a similar low frequency (0.10-0.11) of the Thr allele in both groups. The multivariate odds ratio was 0.68 (95% confidence interval (CI) 0.38-1.22). In the ADCA patients, no significant association between the Ser/Thr polymorphism and survival was observed. Thus, the present results do not support candidacy of the L-myc Ser362Thr polymorphism for the functional polymorphism of the L-myc genomic region. | lld:pubmed |
| pubmed-article:15075794 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15075794 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15075794 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15075794 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15075794 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15075794 | pubmed:issn | 0959-8278 | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:FabbriAA | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:ConteFF | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:CataldiCC | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:DraganiT ATA | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:La VecchiaCC | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:RavagnaniFF | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:PiraEE | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:SpinolaMM | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:IncarboneMM | lld:pubmed |
| pubmed-article:15075794 | pubmed:author | pubmed-author:PelucchiCC | lld:pubmed |
| pubmed-article:15075794 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15075794 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:15075794 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15075794 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15075794 | pubmed:pagination | 87-9 | lld:pubmed |
| pubmed-article:15075794 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:meshHeading | pubmed-meshheading:15075794... | lld:pubmed |
| pubmed-article:15075794 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15075794 | pubmed:articleTitle | A new polymorphism (Ser362Thr) of the L-myc gene is not associated with lung adenocarcinoma risk and prognosis. | lld:pubmed |
| pubmed-article:15075794 | pubmed:affiliation | Department of Experimental Oncology; Thoracic Surgery; Pathology, Istituto Nazionale Tumori, Milan, Italy. spinola@istitutotumori.mi.it | lld:pubmed |
| pubmed-article:15075794 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15075794 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4610 | entrezgene:pubmed | pubmed-article:15075794 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15075794 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15075794 | lld:pubmed |
