| pubmed-article:15071017 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0556025 | lld:lifeskim |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0337910 | lld:lifeskim |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:15071017 | lifeskim:mentions | umls-concept:C0430420 | lld:lifeskim |
| pubmed-article:15071017 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15071017 | pubmed:dateCreated | 2004-4-8 | lld:pubmed |
| pubmed-article:15071017 | pubmed:abstractText | We evaluated a quantitative enzyme immunoassay (trak-C) for hepatitis C virus core antigen (HCV core Ag) by testing serum specimens from 820 injection drug users in Thailand with anti-HCV antibodies. The HCV genotypes in this population include genotypes 3 and 6, which have not been extensively tested with this assay. Among these specimens, 629 (76.7%) yielded positive results, with HCV core Ag concentrations predominantly spanning (35.7%) or above (58.2%) the measurable range of 1.5 to 100 pg/ml. To assess reproducibility, we retested 30 specimens representing six core Ag ranges; the mean coefficient of variation for each range was < or = 9.7% (highest for 1.5 to 25 pg/ml). We also tested 204 specimens of the 820-specimen set for HCV RNA: while 146 (71.6%) were core Ag positive, 168 (82.4%) had detectable HCV RNA, of which 96% were typeable as genotype 3 (39%), 1 (31%), or 6 (26%) by nested reverse transcription-PCR. Among RNA-positive specimens, 86.9% had core Ag; 94% of the RNA negatives were core Ag negative. While there was no apparent bias for detecting core Ag representing the tested genotypes, median quantified results were higher for types 1a and 6 than for genotype 3 (P = 0.01); similarly, the median core Ag concentration was higher in HCV-human immunodeficiency virus-coinfected subjects than in HCV-monoinfected subjects. Our results demonstrated a good correlation between core Ag and HCV RNA in this population with high frequencies of genotypes 3 and 6. Because most core Ag concentrations were greater than those in the measurable range, we recommend a 10-fold dilution of the specimen before quantification. Reproducibility, low technical requirements, and high throughput should make this assay useful for clinical or research monitoring of HCV levels during active infection. | lld:pubmed |
| pubmed-article:15071017 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15071017 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15071017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15071017 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15071017 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15071017 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:ThomasDavid... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:MehtaShruti... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:SuriyanonVina... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:TicehurstJohn... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:WangXiao-Hong... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:CelentanoDavi... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:NelsonKenradK | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:ManeekarnNiwa... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:ThongsawatSat... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:NetskiDale... | lld:pubmed |
| pubmed-article:15071017 | pubmed:author | pubmed-author:Jittiwutikorn... | lld:pubmed |
| pubmed-article:15071017 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15071017 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:15071017 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15071017 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15071017 | pubmed:pagination | 1631-6 | lld:pubmed |
| pubmed-article:15071017 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:meshHeading | pubmed-meshheading:15071017... | lld:pubmed |
| pubmed-article:15071017 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15071017 | pubmed:articleTitle | Hepatitis C virus (HCV) core antigen assay to detect ongoing HCV infection in thai injection drug users. | lld:pubmed |
| pubmed-article:15071017 | pubmed:affiliation | Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland. dnetski1@jhmi.edu | lld:pubmed |
| pubmed-article:15071017 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15071017 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15071017 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15071017 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15071017 | lld:pubmed |
