Linked Life Data

15069697

Source:http://linkedlifedata.com/resource/pubmed/id/15069697

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pubmed-article:15069697pubmed:abstractText5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PPIX) fluorescence has shown an outstanding sensitivity for the assessment of oral lesions, but its application was hampered by low specificity due to the high false-positive rates. The purpose of our study was to explore the feasibility of quantifying PPIX fluorescence images to improve the diagnostic specificity for detecting early oral lesions in vivo. A digitized 5-ALA-mediated endoscopic imaging system was utilized to acquire PPIX fluorescence images from in vivo oral tissues. Forty-nine patients (118 biopsies) with known or suspected premalignant or malignant oral lesions were recruited for ALA-PPIX fluorescence endoscopic imaging. The red and blue channels of PPIX fluorescence images were digitized and stored for fluorescence quantification. The red-to-blue intensity ratios were calculated from the fluorescence images to correlate with histologic findings of the biopsies. The results showed that normal oral mucosa exhibited blue color of the back-scattered excitation light in the fluorescence images, whereas the suspicious lesions displayed bright reddish fluorescence. Applying the red-to-blue intensity ratio (I(R)/I(B)) as a diagnostic algorithm yielded a sensitivity of 92% and 98%, and specificity of 96% and 96%, for separating benign tissue from dysplasia, and cancer tissue, respectively, and a sensitivity and specificity of 98% and 92%, respectively, for differentiating cancer tissue from dysplasia in the oral cavity. Our study demonstrates that quantifying ALA-PPIX fluorescence endoscopic images associated with the red-to-blue intensity ratio as a diagnostic algorithm can provide good differentiation between the different stages of oral premalignancy and malignancy (p<0.0001, unpaired 2-sided Student's t-test), and thus has a potential to significantly improve the noninvasive diagnosis and evaluation of early oral neoplasia in vivo.lld:pubmed
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pubmed-article:15069697pubmed:authorpubmed-author:ZhengWeiWlld:pubmed
pubmed-article:15069697pubmed:authorpubmed-author:OlivoMaliniMlld:pubmed
pubmed-article:15069697pubmed:authorpubmed-author:SooKhee...lld:pubmed
pubmed-article:15069697pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
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pubmed-article:15069697pubmed:pagination295-300lld:pubmed
pubmed-article:15069697pubmed:dateRevised2007-7-24lld:pubmed
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pubmed-article:15069697pubmed:articleTitleThe use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo.lld:pubmed
pubmed-article:15069697pubmed:affiliationDivision of Medical Sciences, National Cancer Centre, Singapore. dmszhw@nccs.com.sglld:pubmed
pubmed-article:15069697pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15069697pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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