| pubmed-article:15059097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15059097 | lifeskim:mentions | umls-concept:C0337611 | lld:lifeskim |
| pubmed-article:15059097 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:15059097 | lifeskim:mentions | umls-concept:C0887969 | lld:lifeskim |
| pubmed-article:15059097 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15059097 | pubmed:dateCreated | 2004-4-2 | lld:pubmed |
| pubmed-article:15059097 | pubmed:abstractText | A considerable body of data has been accumulated which demonstrates that the local lymph node assay (LLNA) can provide a valuable estimation of the contact allergenic potency of a substance. This estimate is obtained via interpolation of the LLNA dose-response curve and is expressed as the concentration of the chemical required to evince a 3-fold stimulation of proliferation in lymph nodes draining the site of application compared to the vehicle-treated controls (EC3). It has also been shown that the EC3 estimates are reproducible and are stable over time. In the present work, we have extended this information by a demonstration of the inherent biological variability surrounding EC3 estimation, using data derived (from a single laboratory) from the testing of isoeugenol as a positive control. Isoeugenol gave EC3 values ranging from 0.5 to 2.6% (n = 29), with a mean and standard deviation of 1.2 +/- 0.6%. Given that EC3 values for a variety of contact allergens range over several orders of magnitude, these results further endorse the utility of EC3 values as a reliable indicator of human contact allergenic potency. | lld:pubmed |
| pubmed-article:15059097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15059097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059097 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15059097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15059097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15059097 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15059097 | pubmed:issn | 0105-1873 | lld:pubmed |
| pubmed-article:15059097 | pubmed:author | pubmed-author:BasketterDavi... | lld:pubmed |
| pubmed-article:15059097 | pubmed:author | pubmed-author:CadbyPeterP | lld:pubmed |
| pubmed-article:15059097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15059097 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:15059097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15059097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15059097 | pubmed:pagination | 15-7 | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
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| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:meshHeading | pubmed-meshheading:15059097... | lld:pubmed |
| pubmed-article:15059097 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15059097 | pubmed:articleTitle | Reproducible prediction of contact allergenic potency using the local lymph node assay. | lld:pubmed |
| pubmed-article:15059097 | pubmed:affiliation | Safety and Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedford, UK. david.basketter@unilever.com | lld:pubmed |
| pubmed-article:15059097 | pubmed:publicationType | Journal Article | lld:pubmed |
