Linked Life Data

15056359

Source:http://linkedlifedata.com/resource/pubmed/id/15056359

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pubmed-article:15056359pubmed:abstractTextDefensin is the predominant inducible immune peptide in Aedes aegypti. In spite of its activity against Gram-positive bacteria in vitro, defensin expression is detected in mosquitoes inoculated with Gram-positive or negative bacteria, or with filarial worms. Defensin transcription and expression are dependent upon bacterial dose; however, translation is inconsistent with transcription because peptide is detectable only in mosquitoes inoculated with large doses. In vitro translation assays provide further evidence for post-transcriptional regulation of defensin. Clearance assays show that a majority of bacteria are cleared before defensin is detected. In gene silencing experiments, no significant difference in mortality was observed between defensin-deficient and control mosquitoes after bacteria inoculation. These studies suggest that defensin may have an alternative function in mosquito immunity.lld:pubmed
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pubmed-article:15056359pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15056359pubmed:articleTitleReassessing the role of defensin in the innate immune response of the mosquito, Aedes aegypti.lld:pubmed
pubmed-article:15056359pubmed:affiliationDepartment of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA.lld:pubmed
pubmed-article:15056359pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15056359pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15056359pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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