Linked Life Data

15051721

Source:http://linkedlifedata.com/resource/pubmed/id/15051721

Statements in which the resource exists.
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pubmed-article:15051721pubmed:abstractTextSynthetic peptides were used in this study to identify a structural element of apolipoprotein (apo) A-I that stimulates cellular cholesterol efflux and stabilizes the ATP binding cassette transporter A1 (ABCA1). Peptides (22-mers) based on helices 1 (amino acids 44-65) and 10 (amino acids 220-241) of apoA-I had high lipid binding affinity but failed to mediate ABCA1-dependent cholesterol efflux, and they lacked the ability to stabilize ABCA1. The addition of helix 9 (amino acids 209-219) to either helix 1 (creates a 1/9 chimera) or 10 (9/10 peptide) endowed cholesterol efflux capability and ABCA1 stabilization activity similar to full-length apoA-I. Adding helix 9 to helix 1 or 10 had only a small effect on lipid binding affinity compared with the 22-mer peptides, indicating that helix length and/or determinants on the polar surface of the amphipathic alpha-helices is important for cholesterol efflux. Cholesterol efflux was specific for the structure created by the 1/9 and 9/10 helical combinations, as 33-mers composed of helices 1 and 3 (1/3), 2/9, and 4/9 failed to mediate cholesterol efflux in an ABCA1-dependent manner. Transposing helices 9 and 10 (10/9 peptide) did not change the class Y structure, hydrophobicity, or amphiphilicity of the helical combination, but the topography of negatively charged amino acids on the polar surface was altered, and the 10/9 peptide neither mediated ABCA1-dependent cholesterol efflux nor stabilized ABCA1 protein. These results suggest that a specific structural element possessing a linear array of acidic residues spanning two apoA-I amphipathic alpha-helices is required to mediate cholesterol efflux and stabilize ABCA1.lld:pubmed
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pubmed-article:15051721pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15051721pubmed:articleTitleIdentification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1.lld:pubmed
pubmed-article:15051721pubmed:affiliationLawrence Berkeley National Laboratory, Donner Laboratory MS1-224, University of California at Berkeley, California 94720, USA.lld:pubmed
pubmed-article:15051721pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15051721pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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