| pubmed-article:15050915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15050915 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:15050915 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15050915 | pubmed:dateCreated | 2004-3-30 | lld:pubmed |
| pubmed-article:15050915 | pubmed:abstractText | IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth and metastasis formation in vivo. NVP-AEW541 is a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor of the IGF-IR, capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. As expected for a specific IGF-IR kinase inhibitor, NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, this orally bioavailable compound inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Thus, NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. | lld:pubmed |
| pubmed-article:15050915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15050915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15050915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15050915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15050915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15050915 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15050915 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:15050915 | pubmed:author | pubmed-author:GaoJiapingJ | lld:pubmed |
| pubmed-article:15050915 | pubmed:author | pubmed-author:MeyerThomasT | lld:pubmed |
| pubmed-article:15050915 | pubmed:author | pubmed-author:FuretPascalP | lld:pubmed |
| pubmed-article:15050915 | pubmed:author | pubmed-author:MartiAndreasA | lld:pubmed |
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| pubmed-article:15050915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15050915 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:15050915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15050915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15050915 | pubmed:pagination | 231-9 | lld:pubmed |
| pubmed-article:15050915 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15050915 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15050915 | pubmed:articleTitle | In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. | lld:pubmed |
| pubmed-article:15050915 | pubmed:affiliation | Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland. | lld:pubmed |
| pubmed-article:15050915 | pubmed:publicationType | Journal Article | lld:pubmed |
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