| pubmed-article:15048073 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C1705316 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C1707310 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15048073 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15048073 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:15048073 | pubmed:dateCreated | 2004-6-3 | lld:pubmed |
| pubmed-article:15048073 | pubmed:abstractText | We examined the mechanism by which estrogen regulates telomerase activity in Caov-3 human ovarian cancer cell lines, which express ER, to determine whether the regulation affects the expression and/or phosphorylation of the telomerase catalytic subunit (hTERT). 17beta-Estradiol (E(2)) induced telomerase activity and hTERT expression. Transient expression assays using luciferase reporter plasmids containing various fragments of hTERT promoter showed that the estrogen-responsive element appeared to be partially responsible for the E(2)-induced activation of the hTERT promoter. Either pretreatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, or transfection with a dominant-negative Akt attenuated the E(2)-induced activation of the hTERT promoter. In addition, estrogen induced the phosphorylation of IkappaB inhibitor protein via the Akt cascade, and cotransfection with a dominant-negative subunit of NFkappaB attenuated the response of the ERE-deleted hTERT promoter to E(2). Moreover, E(2) induced the phosphorylation of hTERT, the association of 14-3-3 protein and NFkappaB with hTERT, and nuclear accumulation of hTERT in an Akt-dependent manner. These results indicate that E(2) induces telomerase activity not only by transcriptional regulation of hTERT via an ERE-dependent mechanism and a PI3K/Akt/NFkappaB cascade, but also by post-transcriptional regulation via Akt-dependent phosphorylation of hTERT. Thus, the phosphorylation of Akt is a key event in the induction of telomerase activity by E(2) in human ovarian cancer cells. | lld:pubmed |
| pubmed-article:15048073 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15048073 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15048073 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15048073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15048073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15048073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15048073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15048073 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15048073 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15048073 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15048073 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:TasakaKeiichi... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:KurachiHirohi... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:MurataYujiY | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:OhmichiMasahi... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:NishioYukihir... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:MabuchiSeijiS | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:KyoSatoruS | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:InoueMasakiM | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:KimuraAkikoA | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:TakahashiTosh... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:Arimoto-Ishid... | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:KawagoeJunJ | lld:pubmed |
| pubmed-article:15048073 | pubmed:author | pubmed-author:OhshimaChikaC | lld:pubmed |
| pubmed-article:15048073 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15048073 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:15048073 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:15048073 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15048073 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15048073 | pubmed:pagination | 4505-15 | lld:pubmed |
| pubmed-article:15048073 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15048073 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15048073 | pubmed:articleTitle | Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines. | lld:pubmed |
| pubmed-article:15048073 | pubmed:affiliation | Department of Obstetrics and Gynecology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. | lld:pubmed |
| pubmed-article:15048073 | pubmed:publicationType | Journal Article | lld:pubmed |
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