| pubmed-article:1504758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:1504758 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:1504758 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1504758 | pubmed:dateCreated | 1992-9-24 | lld:pubmed |
| pubmed-article:1504758 | pubmed:abstractText | 1. The effect of 17 beta-oestradiol on cardiac cell contraction, inward Ca2+ current and intracellular free Ca2+ ([free Ca2+]i) was investigated in guinea-pig single, isolated ventricular myocytes. The changes of cell length were measured by use of a photodiode array, the voltage-clamp experiments were performed with a switch clamp system and [free Ca2+]i was measured with the Ca2+ indicator, Fura-2. 2. 17 beta-Oestradiol (10, 30 microM) caused a decrease in cell shortening at both 22 and 35 degrees C. This negative inotropic effect was accompanied by a decrease in action potential duration mainly brought about by a shortening of the plateau region of the action potential. 17 beta-Oestradiol (10, 30 microM) induced a similar decrease in cell shortening in voltage-clamped and current-clamped cells. 3. In Fura-2 loaded cells, 17 beta-oestradiol (10 and 30 microM) decreased systolic Fura-2 fluorescence to 72 +/- 7% and 47 +/- 4% (n = 6, P less than 0.001) of control respectively. 17 beta-Oestradiol (10 microM) had no significant effect on diastolic Fura-2 fluorescence, but at higher concentration (30 microM) induced a slight decrease in resting Fura-2 fluorescence. The effect of 17 beta-oestradiol was reversible after 1-2 min of washout of the steroid. 4. 17 beta-Oestradiol (10 and 30 microM) decreased the peak inward Ca2+ current (ICa), which was sensitive to [Ca2+]o, dihydropyridines and isoprenaline, to 59 +/- 3% and 39 +/- 5% (n = 7 approximately 9, P less than 0.01) respectively, without producing any significant change in the shape of the current-voltage relationship.5. The recovery time of ICa from inactivation was delayed by 17beta-oestradiol (10microM). The inhibitory effect of 17beta-oestradiol on ICa was less at a holding potential of -80 mV than at -40 mV.6. We conclude that 17beta-oestradiol has a negative inotropic effect on guinea-pig single ventricular myocytes by inhibiting ICa and so reducing systolic [Ca2+]i. 17beta-Oestradiol may therefore have a Ca2+ channel blocking property in guinea-pig isolated ventricular myocytes. | lld:pubmed |
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| pubmed-article:1504758 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1504758 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504758 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1504758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1504758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1504758 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1504758 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:Poole-WilsonP... | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:CollinsPP | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:MochizukiSS | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:SarrelP MPM | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:JiangCC | lld:pubmed |
| pubmed-article:1504758 | pubmed:author | pubmed-author:MacLeodK TKT | lld:pubmed |
| pubmed-article:1504758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1504758 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:1504758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1504758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1504758 | pubmed:pagination | 739-45 | lld:pubmed |
| pubmed-article:1504758 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1504758 | pubmed:meshHeading | pubmed-meshheading:1504758-... | lld:pubmed |
| pubmed-article:1504758 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1504758 | pubmed:articleTitle | Effect of 17 beta-oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea-pig isolated cardiac myocytes. | lld:pubmed |
| pubmed-article:1504758 | pubmed:affiliation | Department of Cardiac Medicine, National Heart and Lung Institute, London. | lld:pubmed |
| pubmed-article:1504758 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1504758 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1504758 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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