| pubmed-article:15046865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0031939 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0332152 | lld:lifeskim |
| pubmed-article:15046865 | lifeskim:mentions | umls-concept:C0162811 | lld:lifeskim |
| pubmed-article:15046865 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:15046865 | pubmed:dateCreated | 2004-3-29 | lld:pubmed |
| pubmed-article:15046865 | pubmed:abstractText | The nocturnal biosynthesis of melatonin in the rat pineal depends on strongly enhanced expression of the enzyme N-acetyltransferase [arylalkylamine N-acetyltransferase (AA-NAT); EC 2.3.1.87]. AA-NAT transcription is stimulated during darkness by adrenergic inputs to the pineal from the suprachiasmatic nucleus (SCN). Nocturnal activation of the AA-NAT promotor following stimulation of pinealocyte adrenoceptors involves cAMP-dependent stimulation of protein kinase A (PKA). The nocturnal rise in AA-NAT depends on the lighting conditions. As compared with light/dark (LD) 12:12, the delay between dark onset and the nocturnal rise in AA-NAT is shortened under long photoperiods and prolonged under short photoperiods. Here, we report that the rapidity of nocturnal AA-NAT induction depends on cAMP inducibility of the gene. Accordingly, cAMP produces a strong AA-NAT response in pineals obtained from rats housed under long photoperiods and a weak AA-NAT response under short photoperiods. Changes in AA-NAT inducibility are fully developed not earlier than after seven cycles. This observation suggests that long-term changes in the photoperiod are necessary to achieve full adjustment of cAMP inducibility of the gene. A direct relationship was found between cAMP-dependent AA-NAT inducibility and the pineal protein kinase A (PKA) activity. As compared to LD 12:12, PKA activity was increased under LD 20:4 and attenuated under LD 4:20. On the basis of the present findings, we suggest that the photoperiod determines the effectiveness of nocturnal AA-NAT induction by long-term modulation of the intrapineal pathway that transmits the cAMP signal to the AA-NAT gene. | lld:pubmed |
| pubmed-article:15046865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15046865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15046865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15046865 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15046865 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:VollrathLutzL | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:HolthuesHeike... | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:EngelLydiaL | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:MathesAlexand... | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:SchwerdtleIsa... | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:HeinrichBetti... | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:PogorzelskiBe... | lld:pubmed |
| pubmed-article:15046865 | pubmed:author | pubmed-author:SpessertRaine... | lld:pubmed |
| pubmed-article:15046865 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15046865 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15046865 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:15046865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15046865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15046865 | pubmed:pagination | 45-55 | lld:pubmed |
| pubmed-article:15046865 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
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| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:meshHeading | pubmed-meshheading:15046865... | lld:pubmed |
| pubmed-article:15046865 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15046865 | pubmed:articleTitle | Rat pineal arylalkylamine-N-acetyltransferase: cyclic AMP inducibility of its gene depends on prior entrained photoperiod. | lld:pubmed |
| pubmed-article:15046865 | pubmed:affiliation | Department of Anatomy, Johannes Gutenberg University, Saarstrasse 19-21, D-55099 Mainz, Germany. | lld:pubmed |
| pubmed-article:15046865 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15046865 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25120 | entrezgene:pubmed | pubmed-article:15046865 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15046865 | lld:entrezgene |
