| pubmed-article:1504369 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1504369 | lifeskim:mentions | umls-concept:C0014264 | lld:lifeskim |
| pubmed-article:1504369 | lifeskim:mentions | umls-concept:C0036974 | lld:lifeskim |
| pubmed-article:1504369 | lifeskim:mentions | umls-concept:C0520990 | lld:lifeskim |
| pubmed-article:1504369 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1504369 | pubmed:dateCreated | 1992-9-18 | lld:pubmed |
| pubmed-article:1504369 | pubmed:abstractText | The sensitivity (LD100) of mice to lipopolysaccharide (LPS) endotoxin and to its toxic moiety, lipid A (LA), increased 500-fold after adrenalectomy (ADX). Inhibition of glucocorticoid synthesis in intact mice by metyrapone had a similar, though less dramatic, sensitizing effect to LPS. In ADX mice, the serum level of tumor necrosis factor-alpha (TNF) was 40-60 times higher than that in controls at 2 h after LPS/LA treatment. In intact mice the serum corticosterone level fell 1 h after lipid A injection to below detectable levels, which was followed by a brisk increase reaching the peak level of 48-50 micrograms/100 ml at 2 h. Both TNF production and the lethal effect of PLS/LA could be inhibited in ADX mice by glucocorticoid treatment. Plasma prolactin was increased significantly 1 h after endotoxin administration in both intact and ADX animals. | lld:pubmed |
| pubmed-article:1504369 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1504369 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1504369 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1504369 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1504369 | pubmed:issn | 0889-1591 | lld:pubmed |
| pubmed-article:1504369 | pubmed:author | pubmed-author:SehonA HAH | lld:pubmed |
| pubmed-article:1504369 | pubmed:author | pubmed-author:BercziII | lld:pubmed |
| pubmed-article:1504369 | pubmed:author | pubmed-author:RamachandraR... | lld:pubmed |
| pubmed-article:1504369 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1504369 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1504369 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1504369 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1504369 | pubmed:pagination | 157-69 | lld:pubmed |
| pubmed-article:1504369 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1504369 | pubmed:meshHeading | pubmed-meshheading:1504369-... | lld:pubmed |
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| pubmed-article:1504369 | pubmed:meshHeading | pubmed-meshheading:1504369-... | lld:pubmed |
| pubmed-article:1504369 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1504369 | pubmed:articleTitle | Neuro-hormonal host defence in endotoxin shock. | lld:pubmed |
| pubmed-article:1504369 | pubmed:affiliation | Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. | lld:pubmed |
| pubmed-article:1504369 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1504369 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1504369 | lld:pubmed |
