| pubmed-article:15039959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0003232 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:15039959 | lifeskim:mentions | umls-concept:C1433601 | lld:lifeskim |
| pubmed-article:15039959 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15039959 | pubmed:dateCreated | 2004-3-24 | lld:pubmed |
| pubmed-article:15039959 | pubmed:abstractText | A liquid chromatography-tandem mass spectrometric (LC/MS/MS) method for the determination of a new ox-azolidinone antibiotic DA-7867, (S)-[N-3-(4-(2-(1-methyl-5-tetrazolyl)-pyridine-5-yl)-3- fl uorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide, in human plasma was developed. DA-7867 and internal standard, linezolid, were extracted from human plasma with ethyl acetate at acidic pH. A reverse-phase LC separation was performed on Luna C(8) column with the mixture of acetonitrile-ammonium formate (10 mm, pH 4.5; 35:65, v/v) as mobile phase. The analytes were determined using an electrospray ionization tandem mass spectrometry in the multiple-reaction-monitoring mode. The lower limits of quanti fi cation for DA-7867 was 2.5 ng/mL. The single liquid-liquid extraction quantitatively recovered DA-7867 and internal standard from plasma samples at the ranges of 82.2-86.7%. DA-7867 was stable in blank human plasma at room temperature for 24 h and following three freeze-thaw cycles. | lld:pubmed |
| pubmed-article:15039959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15039959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15039959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039959 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15039959 | pubmed:issn | 0269-3879 | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:LeeHye WonHW | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:LeeHye SukHS | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:JiHye YoungHY | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:KimWon BaeWB | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:LeeJong JinJJ | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:RheeJae... | lld:pubmed |
| pubmed-article:15039959 | pubmed:author | pubmed-author:ChangSeung... | lld:pubmed |
| pubmed-article:15039959 | pubmed:copyrightInfo | Copyright 2003 John Wiley & Sons, Ltd. | lld:pubmed |
| pubmed-article:15039959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039959 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15039959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039959 | pubmed:pagination | 86-9 | lld:pubmed |
| pubmed-article:15039959 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:meshHeading | pubmed-meshheading:15039959... | lld:pubmed |
| pubmed-article:15039959 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15039959 | pubmed:articleTitle | Liquid chromatography-tandem mass spectrometry for the determination of a new oxazolidinone antibiotic DA-7867 in human plasma. | lld:pubmed |
| pubmed-article:15039959 | pubmed:affiliation | Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy and Medicinal Resources Research Center, Wonkwang University, Iksan 570-749, Korea. | lld:pubmed |
| pubmed-article:15039959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15039959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
