| pubmed-article:15039524 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:15039524 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:15039524 | lifeskim:mentions | umls-concept:C1148362 | lld:lifeskim |
| pubmed-article:15039524 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:15039524 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:15039524 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:15039524 | pubmed:issue | Pt 4 | lld:pubmed |
| pubmed-article:15039524 | pubmed:dateCreated | 2004-3-24 | lld:pubmed |
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| pubmed-article:15039524 | pubmed:abstractText | Complete nucleotide sequences of 19 hepatitis B virus (HBV) isolates of genotype A (HBV/A) were determined and analysed along with those of 20 previously reported HBV/A isolates. Of the 19 HBV/A isolates, six including three from Japan and three from the USA clustered with the 14 HBV/A isolates from Western countries. The remaining 13 isolates including four from The Philippines, two from India, three from Nepal and four from Bangladesh clustered with the six HBV/A isolates reported from The Philippines, South Africa and Malawi. Due to distinct epidemiological distributions, genotype A in the 20 HBV isolates was classified into subtype Ae (e for Europe), and that in the other 19 into subtype Aa (a for Asia and Africa) provisionally. The 19 HBV/Aa isolates had a sequence variation significantly greater than that of the 20 HBV/Ae isolates (2.5+/-0.3 % vs 1.1+/-0.6 %, P<0.0001); they differed by 5.0+/-0.4 % (4.1-6.4 %). The double mutation (T1762/A1764) in the core promoter was significantly more frequent in HBV/Aa isolates than in HBV/Ae isolates (11/19 or 58 % vs 5/20 or 25 %, P<0.01). In the pregenome encapsidation (epsilon) signal, a point mutation from G to A or T at nt 1862 was detected in 16 of the 19 (84 %) HBV/Aa isolates but not in any of the 20 HBV/Ae isolates, which may affect virus replication and translation of hepatitis B e antigen. Subtypes Aa and Ae of genotype A deserve evaluation for any clinical differences between them, with a special reference to hepatocellular carcinoma prevalent in Africa. | lld:pubmed |
| pubmed-article:15039524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15039524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15039524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039524 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15039524 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:TanakaYasuhit... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:UedaRyuzoR | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:KumadaHiromit... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:OritoEtsuroE | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:GishRobert... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:SugauchiFumin... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:MiyakawaYuzoY | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:MizokamiMasas... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:KatoTakanobuT | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:ShresthaSanto... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:KhanMobinM | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:AcharyaSubrat... | lld:pubmed |
| pubmed-article:15039524 | pubmed:author | pubmed-author:GamutanMaria... | lld:pubmed |
| pubmed-article:15039524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039524 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:15039524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039524 | pubmed:pagination | 811-20 | lld:pubmed |
| pubmed-article:15039524 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:meshHeading | pubmed-meshheading:15039524... | lld:pubmed |
| pubmed-article:15039524 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15039524 | pubmed:articleTitle | Epidemiological and sequence differences between two subtypes (Ae and Aa) of hepatitis B virus genotype A. | lld:pubmed |
| pubmed-article:15039524 | pubmed:affiliation | Departments of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. | lld:pubmed |
| pubmed-article:15039524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15039524 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15039524 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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