| pubmed-article:15039422 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C0242633 | lld:lifeskim |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:15039422 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15039422 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:15039422 | pubmed:dateCreated | 2004-5-24 | lld:pubmed |
| pubmed-article:15039422 | pubmed:abstractText | Interleukin 5 (IL-5) plays a unique role in allergic inflammatory responses, and the understanding of molecular mechanisms underlying the generation of IL-5-producing cells is crucial for the regulation of allergic disorders. Differentiation of naive CD4 T cells into type-2 helper (Th2) cells is accompanied by chromatin remodeling including hyperacetylation of histones H3 and H4 in the nucleosomes associated with the IL-4, IL-13, and IL-5 genes. Histone hyperacetylation of the IL-5 gene displayed a delayed kinetics compared with that of the IL-4 and IL-13 genes, suggesting a distinct remodeling mechanism for the IL-5-gene locus. Here we studied the role of CD28 costimulation in the generation of IL-5-producing cells and the histone hyperacetylation of the IL-5 gene locus. CD28-costimulation selectively enhanced histone hyperacetylation of the IL-5 gene locus that appeared to be mediated through NF-kappaB activation and subsequent up-regulation of GATA3. The CD28 costimulation-sensitive histone hyperacetylation spanned almost the entire intergenic region between the IL-5 and RAD50 accompanied with intergenic transcript. Thus, this is the first demonstration that CD28 costimulation controls a chromatin-remodeling process during Th2 cell differentiation. | lld:pubmed |
| pubmed-article:15039422 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15039422 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039422 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15039422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039422 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039422 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039422 | pubmed:month | May | lld:pubmed |
| pubmed-article:15039422 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:SekiNobuoN | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:NakayamaToshi... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:TaniguchiMasa... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:YamashitaMasa... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:KimuraMotokoM | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:HashimotoKaho... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:InamiMasamich... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:HasegawaAkihi... | lld:pubmed |
| pubmed-article:15039422 | pubmed:author | pubmed-author:TendaYoshiyuk... | lld:pubmed |
| pubmed-article:15039422 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039422 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:15039422 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15039422 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039422 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039422 | pubmed:pagination | 23123-33 | lld:pubmed |
| pubmed-article:15039422 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:meshHeading | pubmed-meshheading:15039422... | lld:pubmed |
| pubmed-article:15039422 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15039422 | pubmed:articleTitle | CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cells. | lld:pubmed |
| pubmed-article:15039422 | pubmed:affiliation | Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan. | lld:pubmed |
| pubmed-article:15039422 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15039422 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12487 | entrezgene:pubmed | pubmed-article:15039422 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15039422 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15039422 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15039422 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15039422 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15039422 | lld:pubmed |
