| pubmed-article:15039220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C0011991 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C0021851 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C1121402 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C1521733 | lld:lifeskim |
| pubmed-article:15039220 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15039220 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15039220 | pubmed:dateCreated | 2004-3-24 | lld:pubmed |
| pubmed-article:15039220 | pubmed:abstractText | IL-12 consists of two disulfide-linked subunits, p40 and p35, that form functionally active heterodimers for the induction of Th1 cells. In contrast to IL-12 heterodimers, p40 monomers and homodimers possess inhibitory effects on Th1 cells leading to the creation of a Th2 environment. Although it has been shown that IL-12p40 acts as antagonist of IL-12p70 in vitro, no evidence is currently available whether IL-12p40 is functional in vivo. We now report that IL-12p40 plays an important pathological role in anintestinal allergic disease. A high expression of IL-12p40 protein was demonstrated in epithelial cells, dendritic cells, and macrophages in large but not small intestine of allergic diarrhea-induced mice. Interestingly, neutralization with anti-IL-12p40 mAbs reduced the incidence and delayed the onset of disease development. Lower levels of ovalbumin (OVA)-specific IgE Abs in serum were detected in anti-IL-12p40 mAb-treated mice than in control Ab-treated mice. The secretion of Th2 cytokines and eotaxin by the mononuclear cells isolated from the large intestine of anti-IL-12p40 mAb-treated mice was significantly decreased. Finally, the removal of the IL-12p40 gene resulted in complete inhibition of disease development. These results show that over-expression of IL-12p40 is an important contributing factor for the generation of the dominant Th2-type environment in the large intestine of mice with allergic diarrhea. | lld:pubmed |
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| pubmed-article:15039220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15039220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15039220 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15039220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15039220 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15039220 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:15039220 | pubmed:author | pubmed-author:KiyonoHiroshi... | lld:pubmed |
| pubmed-article:15039220 | pubmed:author | pubmed-author:KweonMi-NaMN | lld:pubmed |
| pubmed-article:15039220 | pubmed:author | pubmed-author:FujihashiKoht... | lld:pubmed |
| pubmed-article:15039220 | pubmed:author | pubmed-author:McGheeJerry... | lld:pubmed |
| pubmed-article:15039220 | pubmed:author | pubmed-author:HinoAyakoA | lld:pubmed |
| pubmed-article:15039220 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15039220 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:15039220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15039220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15039220 | pubmed:pagination | 1327-35 | lld:pubmed |
| pubmed-article:15039220 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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