| pubmed-article:15036623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0020885 | lld:lifeskim |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0234388 | lld:lifeskim |
| pubmed-article:15036623 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:15036623 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15036623 | pubmed:dateCreated | 2004-3-23 | lld:pubmed |
| pubmed-article:15036623 | pubmed:abstractText | We have investigated the effect of blockade of G(i/o) proteins on the electrical activity of S-myenteric neurons from guinea-pig ileum longitudinal muscle-myenteric plexus preparations. Intracellular recordings were made from either control or pertussis toxin (PTX) treated tissues. PTX is known to disrupt the function of G(i/o) proteins. Incubation with PTX (300 ng/ml) induced three main changes in the electrophysiological characteristics of S-neurons: (1) resting membrane potential was more depolarised; (2) fast excitatory postsynaptic potentials (EPSPs) were faster and narrower; and (3) spontaneous fast EPSPs and action potentials were more frequent. Amplitude of slow EPSPs was not modified. This general increase in excitability after blockade of G(i/o) proteins shares characteristics with the slow depolarisation induced by long-lasting trains of low-frequency electrical stimulation and could be mediated by similar mechanisms. Electrophysiological activity of S-myenteric neurons could be modulated by an inhibitory tone, which PTX could modify by either pre- or post-synaptic mechanisms, such as inhibition of the tonic release of inhibitory neurotransmitters and/or intracellular signal transduction involving PTX-sensitive G(i/o) proteins. | lld:pubmed |
| pubmed-article:15036623 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15036623 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15036623 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15036623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15036623 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15036623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15036623 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15036623 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:15036623 | pubmed:author | pubmed-author:MartínM IMI | lld:pubmed |
| pubmed-article:15036623 | pubmed:author | pubmed-author:GoicoecheaCC | lld:pubmed |
| pubmed-article:15036623 | pubmed:author | pubmed-author:AbaloRR | lld:pubmed |
| pubmed-article:15036623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15036623 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:15036623 | pubmed:volume | 356 | lld:pubmed |
| pubmed-article:15036623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15036623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15036623 | pubmed:pagination | 175-8 | lld:pubmed |
| pubmed-article:15036623 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:meshHeading | pubmed-meshheading:15036623... | lld:pubmed |
| pubmed-article:15036623 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15036623 | pubmed:articleTitle | Blockade of Gi/o proteins modifies electrical activity of S-myenteric neurons from guinea-pig ileum. | lld:pubmed |
| pubmed-article:15036623 | pubmed:affiliation | Area Farmacología, Depto. Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n, 28922 Alcorcón, Madrid, Spain. | lld:pubmed |
| pubmed-article:15036623 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15036623 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15036623 | pubmed:publicationType | In Vitro | lld:pubmed |
