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pubmed-article:15036594pubmed:abstractTextEndomorphin 1 (EM1) and endomorphin 2 (EM2) are the endogenous peptides with high affinity and selectivity for the mu-opioid receptor (MOR). We examined whether or not EM1- and EM2-expressing hypothalamic neurons might send their axons to the parabrachial nucleus (PBN), where many MOR-expressing neurons have been observed. Immunofluorescence histochemistry was combined with fluorescent retrograde tract-tracing method. In the rats injected with Fluoro-Gold (FG) into the PBN, some of EM1- and EM2-immunoreactive hypothalamic neurons were labeled retrogradely with FG. The majority of the EM1/FG and EM2/FG double-labeled neurons were distributed in the dorsomedial hypothalamus nucleus, centromedial hypothalamic region, and arcuate nucleus; a few of them were also seen in the periventricular hypothalamic nucleus and posterior hypothalamic nucleus. Endomorphins released from PBN-projecting hypothalamic neurons may modulate the gustatory, autonomic and nociceptive functions through MOR-expressing PBN neurons.lld:pubmed
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pubmed-article:15036594pubmed:authorpubmed-author:UngH LHLlld:pubmed
pubmed-article:15036594pubmed:authorpubmed-author:MizunoNoboruNlld:pubmed
pubmed-article:15036594pubmed:authorpubmed-author:ChenTaoTlld:pubmed
pubmed-article:15036594pubmed:authorpubmed-author:LiYun-QingYQlld:pubmed
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pubmed-article:15036594pubmed:pagination139-42lld:pubmed
pubmed-article:15036594pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15036594pubmed:articleTitleEndomorphin 1- and endomorphin 2-like immunoreactive neurons in the hypothalamus send axons to the parabrachial nucleus in the rat.lld:pubmed
pubmed-article:15036594pubmed:affiliationDepartment of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an 710032, China.lld:pubmed
pubmed-article:15036594pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15036594pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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