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pubmed-article:15031453pubmed:abstractTextOcclusive thrombosis is an important component of small- and large-vessel ischemic stroke. Endogenous tissue plasminogen activator (TPA) is the primary mediator of intravascular fibrinolysis and is predominantly expressed by the endothelium of small vessels. The acute release of TPA is influenced by the TPA -7351C/T polymorphism and therefore may play an important role in the pathogenesis of lacunar stroke. In this study, we investigated the risk of lacunar and nonlacunar ischemic stroke associated with the TPA -7351C/T polymorphism.lld:pubmed
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pubmed-article:15031453pubmed:articleTitleTissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke.lld:pubmed
pubmed-article:15031453pubmed:affiliationDepartment of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville South, South Australia.lld:pubmed
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pubmed-article:15031453pubmed:publicationTypeComparative Studylld:pubmed
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