| pubmed-article:15031117 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C0042567 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C0025485 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C0259902 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C0392761 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C1533716 | lld:lifeskim |
| pubmed-article:15031117 | lifeskim:mentions | umls-concept:C0240795 | lld:lifeskim |
| pubmed-article:15031117 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15031117 | pubmed:dateCreated | 2004-3-19 | lld:pubmed |
| pubmed-article:15031117 | pubmed:abstractText | We report a novel developmental mechanism. Anterior-posterior positional information for the vertebrate trunk is generated by sequential interactions between a timer in the early non-organiser mesoderm and the organiser. The timer is characterised by temporally colinear activation of a series of Hox genes in the early ventral and lateral mesoderm (i.e., the non-organiser mesoderm) of the Xenopus gastrula. This early Hox gene expression is transient, unless it is stabilised by signals from the Spemann organiser. The non-organiser mesoderm and the Spemann organiser undergo timed interactions during gastrulation which lead to the formation of an anterior-posterior axis and stable Hox gene expression. When separated from each other, neither non-organiser mesoderm nor the Spemann organiser is able to induce anterior-posterior pattern formation of the trunk. We present a model describing that convergence and extension continually bring new cells from the non-organiser mesoderm within the range of organiser signals and thereby create patterned axial structures. In doing so, the age of the non-organiser mesoderm, but not the age of the organiser, defines positional values along the anterior-posterior axis. We postulate that the temporal information from the non-organiser mesoderm is linked to mesodermal Hox expression. | lld:pubmed |
| pubmed-article:15031117 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15031117 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15031117 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15031117 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15031117 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15031117 | pubmed:issn | 0012-1606 | lld:pubmed |
| pubmed-article:15031117 | pubmed:author | pubmed-author:DurstonAntony... | lld:pubmed |
| pubmed-article:15031117 | pubmed:author | pubmed-author:WackerStephan... | lld:pubmed |
| pubmed-article:15031117 | pubmed:author | pubmed-author:JansenHans... | lld:pubmed |
| pubmed-article:15031117 | pubmed:author | pubmed-author:McNultyClaire... | lld:pubmed |
| pubmed-article:15031117 | pubmed:author | pubmed-author:HoutzagerErwi... | lld:pubmed |
| pubmed-article:15031117 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15031117 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15031117 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:15031117 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15031117 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15031117 | pubmed:pagination | 207-19 | lld:pubmed |
| pubmed-article:15031117 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:meshHeading | pubmed-meshheading:15031117... | lld:pubmed |
| pubmed-article:15031117 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15031117 | pubmed:articleTitle | Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation. | lld:pubmed |
| pubmed-article:15031117 | pubmed:affiliation | Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT, Utrecht, Netherlands. | lld:pubmed |
| pubmed-article:15031117 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15031117 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:394330 | entrezgene:pubmed | pubmed-article:15031117 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15031117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15031117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15031117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15031117 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15031117 | lld:pubmed |
