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pubmed-article:15030348pubmed:abstractTextIdiopathic acquired generalized anhidrosis is a very rare disease of unknown pathogenesis. We report a 25-year-old man with acquired generalized anhidrosis due to occlusion of the coiled ducts. He did not have sweat secretion over the entire surface of the body, including the palms and soles. Sweat-inducing stimuli provoked tingling pain on the skin. Pilocarpine iontophoresis on the forearm did not induce sweat secretion. Neurological examination did not reveal any abnormality in the central or peripheral nervous system. Skin biopsy showed that the coiled ducts were occluded by an amorphous eosinophilic substance. This amorphous eosinophilic substance was positive with periodic acid-Schiff (PAS) staining and was resistant to digestion by diastase. Electron microscopy demonstrated that the coiled ducts were completely occluded by an amorphous substance. The substance occluding the coiled ducts contained fibrous structures. These findings suggested that the acquired generalized anhidrosis in this patient was caused by occlusion of the coiled ducts by a PAS-positive substance probably derived from dark cell granules.lld:pubmed
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pubmed-article:15030348pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:15030348pubmed:articleTitleIdiopathic acquired generalized anhidrosis due to occlusion of proximal coiled ducts.lld:pubmed
pubmed-article:15030348pubmed:affiliationDepartment of Dermatology, Sapporo Medical University School of Medicine, Chyuo-ku, Minami 1, Nishi 16, Sapporo, Japan.lld:pubmed
pubmed-article:15030348pubmed:publicationTypeJournal Articlelld:pubmed
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